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Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventr...

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Autores principales: Linders, Louisa E., Patrikiou, Lefkothea, Soiza-Reilly, Mariano, Schut, Evelien H. S., van Schaffelaar, Bram F., Böger, Leonard, Wolterink-Donselaar, Inge G., Luijendijk, Mieneke C. M., Adan, Roger A. H., Meye, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653441/
https://www.ncbi.nlm.nih.gov/pubmed/36371405
http://dx.doi.org/10.1038/s41467-022-34625-7
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author Linders, Louisa E.
Patrikiou, Lefkothea
Soiza-Reilly, Mariano
Schut, Evelien H. S.
van Schaffelaar, Bram F.
Böger, Leonard
Wolterink-Donselaar, Inge G.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
Meye, Frank J.
author_facet Linders, Louisa E.
Patrikiou, Lefkothea
Soiza-Reilly, Mariano
Schut, Evelien H. S.
van Schaffelaar, Bram F.
Böger, Leonard
Wolterink-Donselaar, Inge G.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
Meye, Frank J.
author_sort Linders, Louisa E.
collection PubMed
description Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventral tegmental area (VTA), thereby promoting overconsumption of palatable food. Specifically, we show that glutamatergic LHA neurons projecting to the VTA are activated by social stress, after which their synapses onto dopamine neurons are potentiated via AMPA receptor subunit alterations. We find that stress-driven strengthening of these specific synapses increases LHA control over dopamine output in key target areas like the prefrontal cortex. Finally, we demonstrate that while inducing LHA-VTA glutamatergic potentiation increases palatable fat intake, reducing stress-driven potentiation of this connection prevents such stress eating. Overall, this study provides insights in the neural circuit adaptations caused by stress that drive overconsumption of palatable food.
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spelling pubmed-96534412022-11-15 Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food Linders, Louisa E. Patrikiou, Lefkothea Soiza-Reilly, Mariano Schut, Evelien H. S. van Schaffelaar, Bram F. Böger, Leonard Wolterink-Donselaar, Inge G. Luijendijk, Mieneke C. M. Adan, Roger A. H. Meye, Frank J. Nat Commun Article Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventral tegmental area (VTA), thereby promoting overconsumption of palatable food. Specifically, we show that glutamatergic LHA neurons projecting to the VTA are activated by social stress, after which their synapses onto dopamine neurons are potentiated via AMPA receptor subunit alterations. We find that stress-driven strengthening of these specific synapses increases LHA control over dopamine output in key target areas like the prefrontal cortex. Finally, we demonstrate that while inducing LHA-VTA glutamatergic potentiation increases palatable fat intake, reducing stress-driven potentiation of this connection prevents such stress eating. Overall, this study provides insights in the neural circuit adaptations caused by stress that drive overconsumption of palatable food. Nature Publishing Group UK 2022-11-12 /pmc/articles/PMC9653441/ /pubmed/36371405 http://dx.doi.org/10.1038/s41467-022-34625-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Linders, Louisa E.
Patrikiou, Lefkothea
Soiza-Reilly, Mariano
Schut, Evelien H. S.
van Schaffelaar, Bram F.
Böger, Leonard
Wolterink-Donselaar, Inge G.
Luijendijk, Mieneke C. M.
Adan, Roger A. H.
Meye, Frank J.
Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title_full Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title_fullStr Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title_full_unstemmed Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title_short Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
title_sort stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653441/
https://www.ncbi.nlm.nih.gov/pubmed/36371405
http://dx.doi.org/10.1038/s41467-022-34625-7
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