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Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653441/ https://www.ncbi.nlm.nih.gov/pubmed/36371405 http://dx.doi.org/10.1038/s41467-022-34625-7 |
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author | Linders, Louisa E. Patrikiou, Lefkothea Soiza-Reilly, Mariano Schut, Evelien H. S. van Schaffelaar, Bram F. Böger, Leonard Wolterink-Donselaar, Inge G. Luijendijk, Mieneke C. M. Adan, Roger A. H. Meye, Frank J. |
author_facet | Linders, Louisa E. Patrikiou, Lefkothea Soiza-Reilly, Mariano Schut, Evelien H. S. van Schaffelaar, Bram F. Böger, Leonard Wolterink-Donselaar, Inge G. Luijendijk, Mieneke C. M. Adan, Roger A. H. Meye, Frank J. |
author_sort | Linders, Louisa E. |
collection | PubMed |
description | Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventral tegmental area (VTA), thereby promoting overconsumption of palatable food. Specifically, we show that glutamatergic LHA neurons projecting to the VTA are activated by social stress, after which their synapses onto dopamine neurons are potentiated via AMPA receptor subunit alterations. We find that stress-driven strengthening of these specific synapses increases LHA control over dopamine output in key target areas like the prefrontal cortex. Finally, we demonstrate that while inducing LHA-VTA glutamatergic potentiation increases palatable fat intake, reducing stress-driven potentiation of this connection prevents such stress eating. Overall, this study provides insights in the neural circuit adaptations caused by stress that drive overconsumption of palatable food. |
format | Online Article Text |
id | pubmed-9653441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96534412022-11-15 Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food Linders, Louisa E. Patrikiou, Lefkothea Soiza-Reilly, Mariano Schut, Evelien H. S. van Schaffelaar, Bram F. Böger, Leonard Wolterink-Donselaar, Inge G. Luijendijk, Mieneke C. M. Adan, Roger A. H. Meye, Frank J. Nat Commun Article Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventral tegmental area (VTA), thereby promoting overconsumption of palatable food. Specifically, we show that glutamatergic LHA neurons projecting to the VTA are activated by social stress, after which their synapses onto dopamine neurons are potentiated via AMPA receptor subunit alterations. We find that stress-driven strengthening of these specific synapses increases LHA control over dopamine output in key target areas like the prefrontal cortex. Finally, we demonstrate that while inducing LHA-VTA glutamatergic potentiation increases palatable fat intake, reducing stress-driven potentiation of this connection prevents such stress eating. Overall, this study provides insights in the neural circuit adaptations caused by stress that drive overconsumption of palatable food. Nature Publishing Group UK 2022-11-12 /pmc/articles/PMC9653441/ /pubmed/36371405 http://dx.doi.org/10.1038/s41467-022-34625-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Linders, Louisa E. Patrikiou, Lefkothea Soiza-Reilly, Mariano Schut, Evelien H. S. van Schaffelaar, Bram F. Böger, Leonard Wolterink-Donselaar, Inge G. Luijendijk, Mieneke C. M. Adan, Roger A. H. Meye, Frank J. Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title | Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title_full | Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title_fullStr | Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title_full_unstemmed | Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title_short | Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
title_sort | stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653441/ https://www.ncbi.nlm.nih.gov/pubmed/36371405 http://dx.doi.org/10.1038/s41467-022-34625-7 |
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