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Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities
The roots of Euphorbia fischeriana have been used as a traditional Chinese medicine for the treatment of tuberculosis and ringworm. In the current study, diterpenoids from the ethyl acetate extract of the roots E. fischeriana and their cytotoxic effects against five cancer lines were investigated. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653608/ https://www.ncbi.nlm.nih.gov/pubmed/36364087 http://dx.doi.org/10.3390/molecules27217258 |
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author | Zhu, Qin-Feng Xu, Guo-Bo Liao, Shang-Gao Yan, Xue-Long |
author_facet | Zhu, Qin-Feng Xu, Guo-Bo Liao, Shang-Gao Yan, Xue-Long |
author_sort | Zhu, Qin-Feng |
collection | PubMed |
description | The roots of Euphorbia fischeriana have been used as a traditional Chinese medicine for the treatment of tuberculosis and ringworm. In the current study, diterpenoids from the ethyl acetate extract of the roots E. fischeriana and their cytotoxic effects against five cancer lines were investigated. Two new ent-abietane diterpenoids, euphonoids H and I (1–2), as well as their two analogues (3–4) were first isolated from this source. The structures of the two new compounds were elucidated on the basis of spectroscopic data and quantum chemical calculation. Their absolute configurations were assigned via ECD spectrum calculation. The isolated compounds were evaluated for their antiproliferative activities against five cancer cell lines. Compounds 1 and 2 exhibited significant inhibitory effects against human prostate cancers C4-2B and C4-2B/ENZR cell lines with IC(50) values ranging from 4.16 ± 0.42 to 5.74 ± 0.45 μM. |
format | Online Article Text |
id | pubmed-9653608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96536082022-11-15 Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities Zhu, Qin-Feng Xu, Guo-Bo Liao, Shang-Gao Yan, Xue-Long Molecules Article The roots of Euphorbia fischeriana have been used as a traditional Chinese medicine for the treatment of tuberculosis and ringworm. In the current study, diterpenoids from the ethyl acetate extract of the roots E. fischeriana and their cytotoxic effects against five cancer lines were investigated. Two new ent-abietane diterpenoids, euphonoids H and I (1–2), as well as their two analogues (3–4) were first isolated from this source. The structures of the two new compounds were elucidated on the basis of spectroscopic data and quantum chemical calculation. Their absolute configurations were assigned via ECD spectrum calculation. The isolated compounds were evaluated for their antiproliferative activities against five cancer cell lines. Compounds 1 and 2 exhibited significant inhibitory effects against human prostate cancers C4-2B and C4-2B/ENZR cell lines with IC(50) values ranging from 4.16 ± 0.42 to 5.74 ± 0.45 μM. MDPI 2022-10-26 /pmc/articles/PMC9653608/ /pubmed/36364087 http://dx.doi.org/10.3390/molecules27217258 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhu, Qin-Feng Xu, Guo-Bo Liao, Shang-Gao Yan, Xue-Long Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title | Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title_full | Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title_fullStr | Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title_full_unstemmed | Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title_short | Ent-Abietane Diterpenoids from Euphorbia fischeriana and Their Cytotoxic Activities |
title_sort | ent-abietane diterpenoids from euphorbia fischeriana and their cytotoxic activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653608/ https://www.ncbi.nlm.nih.gov/pubmed/36364087 http://dx.doi.org/10.3390/molecules27217258 |
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