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The Potential Role of PPARs in the Fetal Origins of Adult Disease

The fetal origins of adult disease (FOAD) hypothesis holds that events during early development have a profound impact on one’s risk for the development of future adult disease. Studies from humans and animals have demonstrated that many diseases can begin in childhood and are caused by a variety of...

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Autores principales: Guo, Jun, Wu, Jue, He, Qinyuan, Zhang, Mengshu, Li, Hong, Liu, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653757/
https://www.ncbi.nlm.nih.gov/pubmed/36359869
http://dx.doi.org/10.3390/cells11213474
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author Guo, Jun
Wu, Jue
He, Qinyuan
Zhang, Mengshu
Li, Hong
Liu, Yanping
author_facet Guo, Jun
Wu, Jue
He, Qinyuan
Zhang, Mengshu
Li, Hong
Liu, Yanping
author_sort Guo, Jun
collection PubMed
description The fetal origins of adult disease (FOAD) hypothesis holds that events during early development have a profound impact on one’s risk for the development of future adult disease. Studies from humans and animals have demonstrated that many diseases can begin in childhood and are caused by a variety of early life traumas, including maternal malnutrition, maternal disease conditions, lifestyle changes, exposure to toxins/chemicals, improper medication during pregnancy, and so on. Recently, the roles of Peroxisome proliferator-activated receptors (PPARs) in FOAD have been increasingly appreciated due to their wide variety of biological actions. PPARs are members of the nuclear hormone receptor subfamily, consisting of three distinct subtypes: PPARα, β/δ, and γ, highly expressed in the reproductive tissues. By controlling the maturation of the oocyte, ovulation, implantation of the embryo, development of the placenta, and male fertility, the PPARs play a crucial role in the transition from embryo to fetus in developing mammals. Exposure to adverse events in early life exerts a profound influence on the methylation pattern of PPARs in offspring organs, which can affect development and health throughout the life course, and even across generations. In this review, we summarize the latest research on PPARs in the area of FOAD, highlight the important role of PPARs in FOAD, and provide a potential strategy for early prevention of FOAD.
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spelling pubmed-96537572022-11-15 The Potential Role of PPARs in the Fetal Origins of Adult Disease Guo, Jun Wu, Jue He, Qinyuan Zhang, Mengshu Li, Hong Liu, Yanping Cells Review The fetal origins of adult disease (FOAD) hypothesis holds that events during early development have a profound impact on one’s risk for the development of future adult disease. Studies from humans and animals have demonstrated that many diseases can begin in childhood and are caused by a variety of early life traumas, including maternal malnutrition, maternal disease conditions, lifestyle changes, exposure to toxins/chemicals, improper medication during pregnancy, and so on. Recently, the roles of Peroxisome proliferator-activated receptors (PPARs) in FOAD have been increasingly appreciated due to their wide variety of biological actions. PPARs are members of the nuclear hormone receptor subfamily, consisting of three distinct subtypes: PPARα, β/δ, and γ, highly expressed in the reproductive tissues. By controlling the maturation of the oocyte, ovulation, implantation of the embryo, development of the placenta, and male fertility, the PPARs play a crucial role in the transition from embryo to fetus in developing mammals. Exposure to adverse events in early life exerts a profound influence on the methylation pattern of PPARs in offspring organs, which can affect development and health throughout the life course, and even across generations. In this review, we summarize the latest research on PPARs in the area of FOAD, highlight the important role of PPARs in FOAD, and provide a potential strategy for early prevention of FOAD. MDPI 2022-11-02 /pmc/articles/PMC9653757/ /pubmed/36359869 http://dx.doi.org/10.3390/cells11213474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Jun
Wu, Jue
He, Qinyuan
Zhang, Mengshu
Li, Hong
Liu, Yanping
The Potential Role of PPARs in the Fetal Origins of Adult Disease
title The Potential Role of PPARs in the Fetal Origins of Adult Disease
title_full The Potential Role of PPARs in the Fetal Origins of Adult Disease
title_fullStr The Potential Role of PPARs in the Fetal Origins of Adult Disease
title_full_unstemmed The Potential Role of PPARs in the Fetal Origins of Adult Disease
title_short The Potential Role of PPARs in the Fetal Origins of Adult Disease
title_sort potential role of ppars in the fetal origins of adult disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653757/
https://www.ncbi.nlm.nih.gov/pubmed/36359869
http://dx.doi.org/10.3390/cells11213474
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