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Structure-Guide Design and Optimization of Potential Druglikeness Inhibitors for TGFβRI with the Pyrrolopyrimidine Scaffold

Among all types of TGFβ signal blockers, small molecule kinase inhibitors (SMKIs) have attracted wide attention due to their economical production, obvious stability, and ease of oral administration. Nevertheless, SMKIs of TGFβRItypically have low druggability so there are none on the market. In thi...

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Detalles Bibliográficos
Autores principales:	Meng, Dan, Xie, Jiali, Li, Yihao, Li, Ruoyu, Zhou, Hui, Deng, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653795/ https://www.ncbi.nlm.nih.gov/pubmed/36297376 http://dx.doi.org/10.3390/ph15101264

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