Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis

The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis require further study of the factors underlying the progression of this disease. The prominent role of mitochondria in neurons makes this organelle a vulnerable target for CNS diseases. The purpose of this revie...

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Detalles Bibliográficos
Autores principales: Blagov, Alexander V., Sukhorukov, Vasily N., Orekhov, Alexander N., Sazonova, Margarita A., Melnichenko, Alexandra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653869/
https://www.ncbi.nlm.nih.gov/pubmed/36361513
http://dx.doi.org/10.3390/ijms232112725
Descripción
Sumario:The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis require further study of the factors underlying the progression of this disease. The prominent role of mitochondria in neurons makes this organelle a vulnerable target for CNS diseases. The purpose of this review is to consider the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis, as well as to propose new promising therapeutic strategies aimed at restoring mitochondrial function in multiple sclerosis.

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