Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis

The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis require further study of the factors underlying the progression of this disease. The prominent role of mitochondria in neurons makes this organelle a vulnerable target for CNS diseases. The purpose of this revie...

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Detalles Bibliográficos
Autores principales: Blagov, Alexander V., Sukhorukov, Vasily N., Orekhov, Alexander N., Sazonova, Margarita A., Melnichenko, Alexandra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653869/
https://www.ncbi.nlm.nih.gov/pubmed/36361513
http://dx.doi.org/10.3390/ijms232112725
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author Blagov, Alexander V.
Sukhorukov, Vasily N.
Orekhov, Alexander N.
Sazonova, Margarita A.
Melnichenko, Alexandra A.
author_facet Blagov, Alexander V.
Sukhorukov, Vasily N.
Orekhov, Alexander N.
Sazonova, Margarita A.
Melnichenko, Alexandra A.
author_sort Blagov, Alexander V.
collection PubMed
description The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis require further study of the factors underlying the progression of this disease. The prominent role of mitochondria in neurons makes this organelle a vulnerable target for CNS diseases. The purpose of this review is to consider the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis, as well as to propose new promising therapeutic strategies aimed at restoring mitochondrial function in multiple sclerosis.
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spelling pubmed-96538692022-11-15 Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis Blagov, Alexander V. Sukhorukov, Vasily N. Orekhov, Alexander N. Sazonova, Margarita A. Melnichenko, Alexandra A. Int J Mol Sci Review The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis require further study of the factors underlying the progression of this disease. The prominent role of mitochondria in neurons makes this organelle a vulnerable target for CNS diseases. The purpose of this review is to consider the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis, as well as to propose new promising therapeutic strategies aimed at restoring mitochondrial function in multiple sclerosis. MDPI 2022-10-22 /pmc/articles/PMC9653869/ /pubmed/36361513 http://dx.doi.org/10.3390/ijms232112725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blagov, Alexander V.
Sukhorukov, Vasily N.
Orekhov, Alexander N.
Sazonova, Margarita A.
Melnichenko, Alexandra A.
Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title_full Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title_fullStr Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title_full_unstemmed Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title_short Significance of Mitochondrial Dysfunction in the Progression of Multiple Sclerosis
title_sort significance of mitochondrial dysfunction in the progression of multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653869/
https://www.ncbi.nlm.nih.gov/pubmed/36361513
http://dx.doi.org/10.3390/ijms232112725
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