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Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment
As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653885/ https://www.ncbi.nlm.nih.gov/pubmed/36362044 http://dx.doi.org/10.3390/ijms232113258 |
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author | Zhou, Xianghong Chen, Bo Zhang, Zilong Huang, Yin Li, Jinze Wei, Qiang Cao, Dehong Ai, Jianzhong |
author_facet | Zhou, Xianghong Chen, Bo Zhang, Zilong Huang, Yin Li, Jinze Wei, Qiang Cao, Dehong Ai, Jianzhong |
author_sort | Zhou, Xianghong |
collection | PubMed |
description | As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). Macrophages are abundant in the TME, and their different polarization directions can promote or inhibit tumor growth and progression. By regulating biological behaviors, such as macrophage recruitment, infiltration, and polarization, miRNAs can affect various molecular pathways to regulate tumor progression and treatment response. In this review, we discuss in detail the effects of macrophages on tumors and the multifaceted effects of miRNAs on macrophages. We also discuss the potential clinical applications and prospects of targeted therapy based on miRNAs, novel clinical biomarkers, and drug delivery systems. |
format | Online Article Text |
id | pubmed-9653885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96538852022-11-15 Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment Zhou, Xianghong Chen, Bo Zhang, Zilong Huang, Yin Li, Jinze Wei, Qiang Cao, Dehong Ai, Jianzhong Int J Mol Sci Review As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). Macrophages are abundant in the TME, and their different polarization directions can promote or inhibit tumor growth and progression. By regulating biological behaviors, such as macrophage recruitment, infiltration, and polarization, miRNAs can affect various molecular pathways to regulate tumor progression and treatment response. In this review, we discuss in detail the effects of macrophages on tumors and the multifaceted effects of miRNAs on macrophages. We also discuss the potential clinical applications and prospects of targeted therapy based on miRNAs, novel clinical biomarkers, and drug delivery systems. MDPI 2022-10-31 /pmc/articles/PMC9653885/ /pubmed/36362044 http://dx.doi.org/10.3390/ijms232113258 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhou, Xianghong Chen, Bo Zhang, Zilong Huang, Yin Li, Jinze Wei, Qiang Cao, Dehong Ai, Jianzhong Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title | Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title_full | Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title_fullStr | Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title_full_unstemmed | Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title_short | Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment |
title_sort | crosstalk between tumor-associated macrophages and micrornas: a key role in tumor microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653885/ https://www.ncbi.nlm.nih.gov/pubmed/36362044 http://dx.doi.org/10.3390/ijms232113258 |
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