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Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building bloc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654077/ https://www.ncbi.nlm.nih.gov/pubmed/36364457 http://dx.doi.org/10.3390/molecules27217631 |
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author | Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi |
author_facet | Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi |
author_sort | Arifian, Hanggara |
collection | PubMed |
description | Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid–natural compound conjugates that were reported with respect to their backgrounds, the synthetic approach and their bioactivity. Several amino acid–natural compound conjugates have shown enhanced pharmacokinetic characteristics, including absorption and distribution properties, reduced toxicity and increased physiological effects. This approach could offer a potentially effective system of drug discovery that can enable the development of pharmacologically active and pharmacokinetically acceptable molecules. |
format | Online Article Text |
id | pubmed-9654077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96540772022-11-15 Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi Molecules Review Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid–natural compound conjugates that were reported with respect to their backgrounds, the synthetic approach and their bioactivity. Several amino acid–natural compound conjugates have shown enhanced pharmacokinetic characteristics, including absorption and distribution properties, reduced toxicity and increased physiological effects. This approach could offer a potentially effective system of drug discovery that can enable the development of pharmacologically active and pharmacokinetically acceptable molecules. MDPI 2022-11-07 /pmc/articles/PMC9654077/ /pubmed/36364457 http://dx.doi.org/10.3390/molecules27217631 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title | Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title_full | Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title_fullStr | Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title_full_unstemmed | Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title_short | Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results |
title_sort | amino-acid-conjugated natural compounds: aims, designs and results |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654077/ https://www.ncbi.nlm.nih.gov/pubmed/36364457 http://dx.doi.org/10.3390/molecules27217631 |
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