Cargando…

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building bloc...

Descripción completa

Detalles Bibliográficos
Autores principales: Arifian, Hanggara, Maharani, Rani, Megantara, Sandra, Gazzali, Amirah Mohd, Muchtaridi, Muchtaridi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654077/
https://www.ncbi.nlm.nih.gov/pubmed/36364457
http://dx.doi.org/10.3390/molecules27217631
_version_ 1784828839996686336
author Arifian, Hanggara
Maharani, Rani
Megantara, Sandra
Gazzali, Amirah Mohd
Muchtaridi, Muchtaridi
author_facet Arifian, Hanggara
Maharani, Rani
Megantara, Sandra
Gazzali, Amirah Mohd
Muchtaridi, Muchtaridi
author_sort Arifian, Hanggara
collection PubMed
description Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid–natural compound conjugates that were reported with respect to their backgrounds, the synthetic approach and their bioactivity. Several amino acid–natural compound conjugates have shown enhanced pharmacokinetic characteristics, including absorption and distribution properties, reduced toxicity and increased physiological effects. This approach could offer a potentially effective system of drug discovery that can enable the development of pharmacologically active and pharmacokinetically acceptable molecules.
format Online
Article
Text
id pubmed-9654077
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96540772022-11-15 Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi Molecules Review Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid–natural compound conjugates that were reported with respect to their backgrounds, the synthetic approach and their bioactivity. Several amino acid–natural compound conjugates have shown enhanced pharmacokinetic characteristics, including absorption and distribution properties, reduced toxicity and increased physiological effects. This approach could offer a potentially effective system of drug discovery that can enable the development of pharmacologically active and pharmacokinetically acceptable molecules. MDPI 2022-11-07 /pmc/articles/PMC9654077/ /pubmed/36364457 http://dx.doi.org/10.3390/molecules27217631 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Arifian, Hanggara
Maharani, Rani
Megantara, Sandra
Gazzali, Amirah Mohd
Muchtaridi, Muchtaridi
Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title_full Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title_fullStr Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title_full_unstemmed Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title_short Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
title_sort amino-acid-conjugated natural compounds: aims, designs and results
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654077/
https://www.ncbi.nlm.nih.gov/pubmed/36364457
http://dx.doi.org/10.3390/molecules27217631
work_keys_str_mv AT arifianhanggara aminoacidconjugatednaturalcompoundsaimsdesignsandresults
AT maharanirani aminoacidconjugatednaturalcompoundsaimsdesignsandresults
AT megantarasandra aminoacidconjugatednaturalcompoundsaimsdesignsandresults
AT gazzaliamirahmohd aminoacidconjugatednaturalcompoundsaimsdesignsandresults
AT muchtaridimuchtaridi aminoacidconjugatednaturalcompoundsaimsdesignsandresults