Cargando…

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandez-Gil, Beatriz I., Otamendi-Lopez, Andrea, Bechtle, Alexandra, Vazquez-Ramos, Carla A., Qosja, Neda, Suarez-Meade, Paola, Sarabia-Estrada, Rachel, Jentoft, Mark E., Guerrero-Cázares, Hugo, Escames, Germaine, Schiapparelli, Paula, Quiñones-Hinojosa, Alfredo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654239/ https://www.ncbi.nlm.nih.gov/pubmed/36359862 http://dx.doi.org/10.3390/cells11213467

Ejemplares similares

DDRE-33. MELATONIN AS A MASTER METABOLIC SWITCH FOR GLIOBLASTOMA
por: Fernandez-Gil, Beatriz Irene, et al.
Publicado: (2021)

BSCI-27. MELATONIN REDUCES MALIGNANCY OF BREAST CANCER BRAIN METASTATIC CELLS
por: Gil, Beatriz Fernandez, et al.
Publicado: (2019)

SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid models
por: Suarez-Meade, Paola, et al.
Publicado: (2023)

Circulatory shear stress induces molecular changes and side population enrichment in primary tumor-derived lung cancer cells with higher metastatic potential
por: Alvarado-Estrada, Keila, et al.
Publicado: (2021)

The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma
por: Ko, Myungjun, et al.
Publicado: (2022)

Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo
por: Yuan, Wu, et al.
Publicado: (2020)

Human Cerebrospinal Fluid Modulates Pathways Promoting Glioblastoma Malignancy
por: Carrano, Anna, et al.
Publicado: (2021)

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin
por: Schiapparelli, Paula, et al.
Publicado: (2017)

Role of Melatonin in Cancer: Effect on Clock Genes
por: Rodríguez-Santana, César, et al.
Publicado: (2023)

The Role of Mitochondria in Brain Aging and the Effects of Melatonin
por: Escames, Germaine, et al.
Publicado: (2010)

Protective Effects of Melatonin on the Skin: Future Perspectives
por: Rusanova, Iryna, et al.
Publicado: (2019)

Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function
por: Guerra-Librero, Ana, et al.
Publicado: (2021)

Engineering Three-Dimensional Tumor Models to Study Glioma Cancer Stem Cells and Tumor Microenvironment
por: Ruiz-Garcia, Henry, et al.
Publicado: (2020)

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment
por: Aranda-Martínez, Paula, et al.
Publicado: (2023)

Chitosan-Based Non-viral Gene and Drug Delivery Systems for Brain Cancer
por: Lara-Velazquez, Montserrat, et al.
Publicado: (2020)

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?
por: Romero, Alejandro, et al.
Publicado: (2020)

Oral Mucositis: Melatonin Gel an Effective New Treatment
por: Abdel Moneim, Ahmed Esmat, et al.
Publicado: (2017)

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151()()
por: Tilghman, Jessica, et al.
Publicado: (2016)

Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
por: Florido, Javier, et al.
Publicado: (2022)

The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases
por: Aranda-Martínez, Paula, et al.
Publicado: (2022)

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy
por: Fernandez-Gil, Beatriz I., et al.
Publicado: (2019)

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation
por: Garzon-Muvdi, Tomas, et al.
Publicado: (2012)

Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo
por: Guerrero-Cázares, Hugo, et al.
Publicado: (2014)

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging
por: Fernández-Ortiz, Marisol, et al.
Publicado: (2020)

Influence of Basement Membrane Proteins and Endothelial Cell-Derived Factors on the Morphology of Human Fetal-Derived Astrocytes in 2D
por: Levy, Amanda F., et al.
Publicado: (2014)

Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging
por: Sayed, Ramy K. A., et al.
Publicado: (2020)

Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells
por: Huang, Yu-Ja, et al.
Publicado: (2016)

Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas
por: Pendleton, Courtney, et al.
Publicado: (2013)

The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle
por: Sayed, Ramy KA, et al.
Publicado: (2021)

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage
por: Sayed, Ramy K. A., et al.
Publicado: (2021)

The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
por: Capilla-Gonzalez, Vivian, et al.
Publicado: (2013)

A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma
por: Kondapalli, Kalyan C., et al.
Publicado: (2015)

The Relationship between Clock Genes, Sirtuin 1, and Mitochondrial Activity in Head and Neck Squamous Cell Cancer: Effects of Melatonin Treatment
por: Rodríguez-Santana, César, et al.
Publicado: (2023)

Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
por: Fernández-Ortiz, Marisol, et al.
Publicado: (2022)

Preoperative Stereotactic Radiosurgery for Glioblastoma
por: Lehrer, Eric J., et al.
Publicado: (2022)

A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit
por: Mansilla‐Roselló, Alfonso, et al.
Publicado: (2022)

Intracellular Ca(2 +) Imbalance Critically Contributes to Paraptosis
por: Kim, Eunhee, et al.
Publicado: (2021)

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine
por: Plummer, Simon, et al.
Publicado: (2019)

The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer
por: Alfarouk, Khalid O., et al.
Publicado: (2020)

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases
por: López, Ana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4et5cdfjhv9uvfhsnss9m3skdi