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In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles
Silver nanoparticles (AgNPs) are widely used commercially due to their antimicrobial effects. Little is known about the effect of AgNPs on neural transmission and pain response. The aim of this study was to assess the anti-nociceptive activity of AgNPs. AgNPs were prepared at 16 ug/mL, white albino...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654273/ https://www.ncbi.nlm.nih.gov/pubmed/36364085 http://dx.doi.org/10.3390/molecules27217259 |
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author | Morsi, Shereen Pittala, Valeria Alqudah, Mohammad Haider, Mohamed Greish, Khaled |
author_facet | Morsi, Shereen Pittala, Valeria Alqudah, Mohammad Haider, Mohamed Greish, Khaled |
author_sort | Morsi, Shereen |
collection | PubMed |
description | Silver nanoparticles (AgNPs) are widely used commercially due to their antimicrobial effects. Little is known about the effect of AgNPs on neural transmission and pain response. The aim of this study was to assess the anti-nociceptive activity of AgNPs. AgNPs were prepared at 16 ug/mL, white albino rats were injected with various doses of AgNPs, and challenged using a hot-plate test and paw withdrawal latency (PWL) was measured. The chronic constriction injury (CCI) model was utilized to evaluate the pedal withdrawal reflex and tail withdrawal reflex. An electrophysiological study was conducted utilizing colon longitudinal muscle strips. AgNPs increased the latency of PWL in a dose-dependent matter over the duration of 6 h. The paw withdrawal threshold in animals with CCI significantly increased after AgNPs administration. In isolated colon longitudinal muscle strips, AgNPs significantly reduced the colonic migrating motor complexes (MMCs) and contraction. This action was completely reversed after removing the AgNPs and adding acetylcholine to the preparation. In this study, AgNPs showed significant anti-nociception properties. To our knowledge, this is the first report to describe this pharmacological action of AgNPs. |
format | Online Article Text |
id | pubmed-9654273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96542732022-11-15 In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles Morsi, Shereen Pittala, Valeria Alqudah, Mohammad Haider, Mohamed Greish, Khaled Molecules Article Silver nanoparticles (AgNPs) are widely used commercially due to their antimicrobial effects. Little is known about the effect of AgNPs on neural transmission and pain response. The aim of this study was to assess the anti-nociceptive activity of AgNPs. AgNPs were prepared at 16 ug/mL, white albino rats were injected with various doses of AgNPs, and challenged using a hot-plate test and paw withdrawal latency (PWL) was measured. The chronic constriction injury (CCI) model was utilized to evaluate the pedal withdrawal reflex and tail withdrawal reflex. An electrophysiological study was conducted utilizing colon longitudinal muscle strips. AgNPs increased the latency of PWL in a dose-dependent matter over the duration of 6 h. The paw withdrawal threshold in animals with CCI significantly increased after AgNPs administration. In isolated colon longitudinal muscle strips, AgNPs significantly reduced the colonic migrating motor complexes (MMCs) and contraction. This action was completely reversed after removing the AgNPs and adding acetylcholine to the preparation. In this study, AgNPs showed significant anti-nociception properties. To our knowledge, this is the first report to describe this pharmacological action of AgNPs. MDPI 2022-10-26 /pmc/articles/PMC9654273/ /pubmed/36364085 http://dx.doi.org/10.3390/molecules27217259 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Morsi, Shereen Pittala, Valeria Alqudah, Mohammad Haider, Mohamed Greish, Khaled In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title | In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title_full | In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title_fullStr | In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title_full_unstemmed | In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title_short | In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles |
title_sort | in vivo evaluation of anti-nociceptive effects of silver nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654273/ https://www.ncbi.nlm.nih.gov/pubmed/36364085 http://dx.doi.org/10.3390/molecules27217259 |
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