Determination of Genotoxic Impurity N-Nitroso-N-methyl-4-aminobutyric Acid in Four Sartan Substances through Using Liquid Chromatography–Tandem Mass Spectrometry

N-nitroso-N-methyl-4-aminobutyric acid (NMBA) is the third N-nitrosamine impurity found in sartans. Herein, a sensitive and stable LC-MS/MS method with multiple reactions monitoring mode has been developed for the quantitative determination of NMBA in four sartan substances. The effective separation...

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Detalles Bibliográficos
Autores principales: Xie, Bin, Guo, Dong, Mai, Binliang, Fan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654383/
https://www.ncbi.nlm.nih.gov/pubmed/36364326
http://dx.doi.org/10.3390/molecules27217498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654383/
https://www.ncbi.nlm.nih.gov/pubmed/36364326
http://dx.doi.org/10.3390/molecules27217498

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