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Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17

The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling pathways. The maturation and function of ADAM17 is controlled by the seven-membrane-spanning proteins iRhoms1 and 2. The functional properties of the ADAM17/iRhom1 and ADAM17/iRhom2 complexes differ, in that stimulat...

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Detalles Bibliográficos
Autores principales:	Zhao, Yi, Dávila, Eliud Morales, Li, Xue, Tang, Beiyu, Rabinowitsch, Ariana I., Perez-Aguilar, Jose Manuel, Blobel, Carl P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654401/ https://www.ncbi.nlm.nih.gov/pubmed/36361585 http://dx.doi.org/10.3390/ijms232112796

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