Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility

Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor me...

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Detalles Bibliográficos
Autores principales: Petrik, József, Verbanac, Donatella, Fabijanec, Marija, Hulina-Tomašković, Andrea, Čeri, Andrea, Somborac-Bačura, Anita, Petlevski, Roberta, Grdić Rajković, Marija, Rumora, Lada, Krušlin, Božo, Štefanović, Mario, Ljubičić, Neven, Baršić, Neven, Hanžek, Antonija, Bočkor, Luka, Ćelap, Ivana, Demirović, Alma, Barišić, Karmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654465/
https://www.ncbi.nlm.nih.gov/pubmed/36362369
http://dx.doi.org/10.3390/ijms232113582
Descripción
Sumario:Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneous spread are considered crucial in the formation of tumor metastases. The analysis of circulating tumor cells (CTCs) and CTC clusters in the blood can be used for the early detection of invasive cancer. Moreover, CTCs have a prognostic significance in the monitoring of a malignant disease or the response to chemotherapy. This work presents an overview of the research conducted on CTCs with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with CRC.

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