APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that requires further pathological elucidation to establish effective treatment strategies. We previously showed that amyloid β (Aβ) toxic conformer with a turn at positions 22–23 is essential for forming highly toxic oligomers. In...

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Detalles Bibliográficos
Autores principales: Maki, Takahito, Sawahata, Masahito, Akutsu, Ichiro, Amaike, Shohei, Hiramatsu, Genki, Uta, Daisuke, Izuo, Naotaka, Shimizu, Takahiko, Irie, Kazuhiro, Kume, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654501/
https://www.ncbi.nlm.nih.gov/pubmed/36362046
http://dx.doi.org/10.3390/ijms232113259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654501/
https://www.ncbi.nlm.nih.gov/pubmed/36362046
http://dx.doi.org/10.3390/ijms232113259

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