Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach

The SARS-CoV-2 non-structural protein 13 (nsp13) helicase is an essential enzyme for viral replication and has been identified as an attractive target for the development of new antiviral drugs. In detail, the helicase catalyzes the unwinding of double-stranded DNA or RNA in a 5′ to 3′ direction and...

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Detalles Bibliográficos
Autores principales: Romeo, Isabella, Ambrosio, Francesca Alessandra, Costa, Giosuè, Corona, Angela, Alkhatib, Mohammad, Salpini, Romina, Lemme, Saverio, Vergni, Davide, Svicher, Valentina, Santoro, Maria Mercedes, Tramontano, Enzo, Ceccherini-Silberstein, Francesca, Artese, Anna, Alcaro, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654784/
https://www.ncbi.nlm.nih.gov/pubmed/36364347
http://dx.doi.org/10.3390/molecules27217522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654784/
https://www.ncbi.nlm.nih.gov/pubmed/36364347
http://dx.doi.org/10.3390/molecules27217522

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