Structure-Based Virtual Screening and De Novo Design to Identify Submicromolar Inhibitors of G2019S Mutant of Leucine-Rich Repeat Kinase 2

Missense mutations of leucine-rich repeat kinase 2 (LRRK2), including the G2019S mutant, are responsible for the pathogenesis of Parkinson’s disease. In this work, structure-based virtual screening of a large chemical library was carried out to identify a number of novel inhibitors of the G2019S mut...

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Autores principales: Park, Hwangseo, Kim, Taeho, Kim, Kewon, Jang, Ahyoung, Hong, Sungwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654793/
https://www.ncbi.nlm.nih.gov/pubmed/36361616
http://dx.doi.org/10.3390/ijms232112825

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