Cargando…

Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma

Slow and progressive loss of retinal ganglion cells (RGCs) is the main characteristic of glaucoma, the second leading cause of blindness worldwide. Previous studies have shown that impaired mitochondrial dynamics could facilitate retinal neurodegeneration. Mitochondrial dynamics are regulated direct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tonner, Henrik, Hunn, Selina, Auler, Nadine, Schmelter, Carsten, Pfeiffer, Norbert, Grus, Franz H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654827/ https://www.ncbi.nlm.nih.gov/pubmed/36362420 http://dx.doi.org/10.3390/ijms232113618

Ejemplares similares

A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma
por: Tonner, Henrik, et al.
Publicado: (2022)

Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways
por: Auler, Nadine, et al.
Publicado: (2021)

Autoantigens in the trabecular meshwork and glaucoma‐specific alterations in the natural autoantibody repertoire
por: Beutgen, Vanessa M, et al.
Publicado: (2020)

Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1
por: Fomo, Kristian Nzogang, et al.
Publicado: (2022)

Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy
por: Schmelter, Carsten, et al.
Publicado: (2019)

Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Networks in Retinal Tissues
por: Schmelter, Carsten, et al.
Publicado: (2021)

Contribution of the Commensal Microflora to the Immunological Homeostasis and the Importance of Immune-Related Drug Development for Clinical Applications
por: Beutgen, Vanessa M., et al.
Publicado: (2021)

Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma
por: Beutgen, Vanessa M., et al.
Publicado: (2021)

Glaucoma related Proteomic Alterations in Human Retina Samples
por: Funke, Sebastian, et al.
Publicado: (2016)

Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A)
por: Schmelter, Carsten, et al.
Publicado: (2023)

Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells
por: Bell, Katharina, et al.
Publicado: (2012)

Lectin-Based Affinity Enrichment and Characterization of N-Glycoproteins from Human Tear Film by Mass Spectrometry
por: Schmelter, Carsten, et al.
Publicado: (2023)

Comparison of Two Solid-Phase Extraction (SPE) Methods for the Identification and Quantification of Porcine Retinal Protein Markers by LC-MS/MS
por: Schmelter, Carsten, et al.
Publicado: (2018)

An In-Depth View of the Porcine Trabecular Meshwork Proteome
por: Funke, Sebastian, et al.
Publicado: (2019)

Autoantibody Biomarker Discovery in Primary Open Angle Glaucoma Using Serological Proteome Analysis (SERPA)
por: Beutgen, Vanessa M., et al.
Publicado: (2019)

Comparative Quantitative Analysis of Porcine Optic Nerve Head and Retina Subproteomes
por: Funke, Sebastian, et al.
Publicado: (2019)

Modulation of the Immune System for the Treatment of Glaucoma
por: Bell, Katharina, et al.
Publicado: (2018)

Longitudinal Analysis of Serum Autoantibody-Reactivities in Patients with Primary Open Angle Glaucoma and Optic Disc Hemorrhage
por: Lorenz, Katrin, et al.
Publicado: (2016)

Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma
por: Lauzi, Jasmin, et al.
Publicado: (2019)

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms
por: Altschuler, Yoram, et al.
Publicado: (1998)

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina
por: Gramlich, Oliver W., et al.
Publicado: (2013)

Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway
por: Bell, Katharina, et al.
Publicado: (2015)

Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
por: Teister, J., et al.
Publicado: (2017)

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway
por: Wilding, Corina, et al.
Publicado: (2014)

The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model
por: Anders, Fabian, et al.
Publicado: (2017)

Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma
por: Gramlich, Oliver W., et al.
Publicado: (2016)

Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma
por: Anders, Fabian, et al.
Publicado: (2017)

Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry
por: Hoffmann, Esther M, et al.
Publicado: (2004)

Dynamin 1 Is Required for Memory Formation
por: Fà, Mauro, et al.
Publicado: (2014)

Age related retinal Ganglion cell susceptibility in context of autophagy deficiency
por: Bell, Katharina, et al.
Publicado: (2020)

Dynamin-Like Protein B of Dictyostelium Contributes to Cytokinesis Cooperatively with Other Dynamins
por: Fujimoto, Koushiro, et al.
Publicado: (2019)

Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease
por: Jiang, Sirui, et al.
Publicado: (2019)

Insights into dynamin-associated disorders through analysis of equivalent mutations in the yeast dynamin Vps1
por: Moustaq, Laila, et al.
Publicado: (2016)

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients
por: Perumal, Natarajan, et al.
Publicado: (2016)

Dynamin-Related Protein 1 at the Crossroads of Cancer
por: Lima, Ana Rita, et al.
Publicado: (2018)

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
por: Griparic, Lorena, et al.
Publicado: (2007)

SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features
por: Gewehr, Lucas, et al.
Publicado: (2023)

Phosphoproteome Profiling Reveals Multifunctional Protein NPM1 as part of the Irradiation Response of Tumor Cells
por: Wiesmann, Nadine, et al.
Publicado: (2018)

A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis
por: Wu, Yumei, et al.
Publicado: (2014)

Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury
por: Park, Dong-Ju, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6tijnfnb7hdcc0jntr1mm3en8p