Native Mass Spectrometry Coupled to Spectroscopic Methods to Investigate the Effect of Soybean Isoflavones on Structural Stability and Aggregation of Zinc Deficient and Metal-Free Superoxide Dismutase

The deficiency or wrong combination of metal ions in Cu, Zn-superoxide dismutase (SOD1), is regarded as one of the main factors causing the aggregation of SOD1 and then inducing amyotrophic lateral sclerosis (ALS). A ligands-targets screening process based on native electrospray ionization ion mobil...

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Detalles Bibliográficos
Autores principales: Bian, Xinyu, Zhuang, Xiaoyu, Xing, Junpeng, Liu, Shu, Liu, Zhiqiang, Song, Fengrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654870/
https://www.ncbi.nlm.nih.gov/pubmed/36364128
http://dx.doi.org/10.3390/molecules27217303

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