Cargando…
Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)
In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in diges...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654937/ https://www.ncbi.nlm.nih.gov/pubmed/36364711 http://dx.doi.org/10.3390/nu14214448 |
_version_ | 1784829060687331328 |
---|---|
author | Martin, Pierre Botsen, Damien Brugel, Mathias Bertin, Eric Carlier, Claire Mahmoudi, Rachid Slimano, Florian Perrier, Marine Bouché, Olivier |
author_facet | Martin, Pierre Botsen, Damien Brugel, Mathias Bertin, Eric Carlier, Claire Mahmoudi, Rachid Slimano, Florian Perrier, Marine Bouché, Olivier |
author_sort | Martin, Pierre |
collection | PubMed |
description | In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (<27 kg (men); <16 kg (women)). DLT was defined as any toxicity leading to dose reduction, treatment delay, or permanent discontinuation. We also performed an exploratory analysis in patients below the included population’s median HGS. A total of 244 patients were included. According to EWGSOP2 criteria, 23 patients had pre-therapeutic dynapenia (9.4%). With our exploratory median-based threshold (34 kg for men; 22 kg for women), 107 patients were dynapenic (43.8%). For each threshold, dynapenia was not an independent predictive factor of overall DLT and neurotoxicity. Dynapenic patients according to EWGSOP2 definition experienced more hand-foot syndrome (p = 0.007). Low HGS according to our exploratory threshold was associated with more all-grade asthenia (p = 0.014), anemia (p = 0.006), and asthenia with DLT (p = 0.029). Pre-therapeutic dynapenia was not a predictive factor for overall DLT and neurotoxicity in digestive cancer patients but could be a predictive factor of chemotherapy-induced anemia and asthenia. There is a need to better define the threshold of dynapenia in cancer patients. |
format | Online Article Text |
id | pubmed-9654937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96549372022-11-15 Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) Martin, Pierre Botsen, Damien Brugel, Mathias Bertin, Eric Carlier, Claire Mahmoudi, Rachid Slimano, Florian Perrier, Marine Bouché, Olivier Nutrients Article In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (<27 kg (men); <16 kg (women)). DLT was defined as any toxicity leading to dose reduction, treatment delay, or permanent discontinuation. We also performed an exploratory analysis in patients below the included population’s median HGS. A total of 244 patients were included. According to EWGSOP2 criteria, 23 patients had pre-therapeutic dynapenia (9.4%). With our exploratory median-based threshold (34 kg for men; 22 kg for women), 107 patients were dynapenic (43.8%). For each threshold, dynapenia was not an independent predictive factor of overall DLT and neurotoxicity. Dynapenic patients according to EWGSOP2 definition experienced more hand-foot syndrome (p = 0.007). Low HGS according to our exploratory threshold was associated with more all-grade asthenia (p = 0.014), anemia (p = 0.006), and asthenia with DLT (p = 0.029). Pre-therapeutic dynapenia was not a predictive factor for overall DLT and neurotoxicity in digestive cancer patients but could be a predictive factor of chemotherapy-induced anemia and asthenia. There is a need to better define the threshold of dynapenia in cancer patients. MDPI 2022-10-22 /pmc/articles/PMC9654937/ /pubmed/36364711 http://dx.doi.org/10.3390/nu14214448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martin, Pierre Botsen, Damien Brugel, Mathias Bertin, Eric Carlier, Claire Mahmoudi, Rachid Slimano, Florian Perrier, Marine Bouché, Olivier Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title | Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title_full | Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title_fullStr | Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title_full_unstemmed | Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title_short | Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX) |
title_sort | association of low handgrip strength with chemotherapy toxicity in digestive cancer patients: a comprehensive observational cohort study (fightdigotox) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654937/ https://www.ncbi.nlm.nih.gov/pubmed/36364711 http://dx.doi.org/10.3390/nu14214448 |
work_keys_str_mv | AT martinpierre associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT botsendamien associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT brugelmathias associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT bertineric associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT carlierclaire associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT mahmoudirachid associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT slimanoflorian associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT perriermarine associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox AT boucheolivier associationoflowhandgripstrengthwithchemotherapytoxicityindigestivecancerpatientsacomprehensiveobservationalcohortstudyfightdigotox |