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The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes

SIMPLE SUMMARY: The assessment of uric acid levels in snakes is an important part of the diagnosis of renal diseases. In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. However, fasting status is not routinely considered when sa...

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Autores principales: Halán, Miloš, Kottferová, Lucia, Račka, Karol, Lam, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655144/
https://www.ncbi.nlm.nih.gov/pubmed/36359083
http://dx.doi.org/10.3390/ani12212959
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author Halán, Miloš
Kottferová, Lucia
Račka, Karol
Lam, Anthony
author_facet Halán, Miloš
Kottferová, Lucia
Račka, Karol
Lam, Anthony
author_sort Halán, Miloš
collection PubMed
description SIMPLE SUMMARY: The assessment of uric acid levels in snakes is an important part of the diagnosis of renal diseases. In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. However, fasting status is not routinely considered when sampling reptile blood. The investigation aims to better understand the feed-induced changes that occur and render the analysis of this parameter a more potent diagnostic tool. A study has shown that feeding snakes lead to substantial elevations in uric acid values, with postprandial concentrations significantly elevated for up to 8 days after feeding. To prevent misdiagnosis and distinguish temporary hyperuricemia from clinically relevant increases, it is recommended that sufficient data on time since the last feeding be collected, as well as repeated samples after weeks of fasting. ABSTRACT: In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. Plasma biochemical values in reptiles may be affected by species, age, season, and nutritional state. However, fasting status is not routinely considered when sampling reptile blood. Assessing uric acid levels in snakes is an important part of the diagnosis of the renal disease. However, the use of this biochemical indicator is undervalued without knowledge of natural uric acid fluctuations and the lack of differentiation from pathological changes. This study aimed to look at the relationship between snake feeding and uric acid concentrations. The investigation aims to better understand the feed-induced changes that occur and render the analysis of this biochemical parameter a more potent diagnostic tool. The study used ten snakes belonging to seven species, and basal uric acid values were evaluated by blood biochemical analysis before feeding. The snakes were fed in two rounds, with successive blood sampling and monitoring of uric acid changes carried out for each. The snakes were fed approximately 50% more with the second round of feeding to investigate the relationship between food supply and uric acid level. The findings show feeding led to substantial elevations in uric acid values, whereby postprandial concentrations were significantly elevated for up to 8 days after feeding. The findings show the significant changes in uric acid levels that occur after feeding and the similarities between postprandial rises in uric acid and those reported in snakes with renal disease. To minimize misdiagnosis and differentiate transient postprandial hyperuricemia from pathological increases, it is recommended that sufficient anamnestic data on time since the last feeding be collected, as well as repeated samples following weeks of fasting. This knowledge is crucial because the amount of feed in terms of intensity and volume has a significant effect on uric acid levels in the blood of snakes.
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spelling pubmed-96551442022-11-15 The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes Halán, Miloš Kottferová, Lucia Račka, Karol Lam, Anthony Animals (Basel) Article SIMPLE SUMMARY: The assessment of uric acid levels in snakes is an important part of the diagnosis of renal diseases. In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. However, fasting status is not routinely considered when sampling reptile blood. The investigation aims to better understand the feed-induced changes that occur and render the analysis of this parameter a more potent diagnostic tool. A study has shown that feeding snakes lead to substantial elevations in uric acid values, with postprandial concentrations significantly elevated for up to 8 days after feeding. To prevent misdiagnosis and distinguish temporary hyperuricemia from clinically relevant increases, it is recommended that sufficient data on time since the last feeding be collected, as well as repeated samples after weeks of fasting. ABSTRACT: In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. Plasma biochemical values in reptiles may be affected by species, age, season, and nutritional state. However, fasting status is not routinely considered when sampling reptile blood. Assessing uric acid levels in snakes is an important part of the diagnosis of the renal disease. However, the use of this biochemical indicator is undervalued without knowledge of natural uric acid fluctuations and the lack of differentiation from pathological changes. This study aimed to look at the relationship between snake feeding and uric acid concentrations. The investigation aims to better understand the feed-induced changes that occur and render the analysis of this biochemical parameter a more potent diagnostic tool. The study used ten snakes belonging to seven species, and basal uric acid values were evaluated by blood biochemical analysis before feeding. The snakes were fed in two rounds, with successive blood sampling and monitoring of uric acid changes carried out for each. The snakes were fed approximately 50% more with the second round of feeding to investigate the relationship between food supply and uric acid level. The findings show feeding led to substantial elevations in uric acid values, whereby postprandial concentrations were significantly elevated for up to 8 days after feeding. The findings show the significant changes in uric acid levels that occur after feeding and the similarities between postprandial rises in uric acid and those reported in snakes with renal disease. To minimize misdiagnosis and differentiate transient postprandial hyperuricemia from pathological increases, it is recommended that sufficient anamnestic data on time since the last feeding be collected, as well as repeated samples following weeks of fasting. This knowledge is crucial because the amount of feed in terms of intensity and volume has a significant effect on uric acid levels in the blood of snakes. MDPI 2022-10-27 /pmc/articles/PMC9655144/ /pubmed/36359083 http://dx.doi.org/10.3390/ani12212959 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Halán, Miloš
Kottferová, Lucia
Račka, Karol
Lam, Anthony
The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title_full The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title_fullStr The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title_full_unstemmed The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title_short The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes
title_sort amount of food ingested and its impact on the level of uric acid in the blood plasma of snakes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655144/
https://www.ncbi.nlm.nih.gov/pubmed/36359083
http://dx.doi.org/10.3390/ani12212959
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