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IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings

The ex vivo expansion and maintenance of long-term hematopoietic stem cells (LT-HSC) is crucial for stem cell-based gene therapy. A combination of stem cell factor (SCF), thrombopoietin (TPO), FLT3 ligand (FLT3) and interleukin 3 (IL3) cytokines has been commonly used in clinical settings for the ex...

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Detalles Bibliográficos
Autores principales:	Tajer, Parisa, Canté-Barrett, Kirsten, Naber, Brigitta A. E., Vloemans, Sandra A., van Eggermond, Marja C. J. A., van der Hoorn, Marie-Louise, Pike-Overzet, Karin, Staal, Frank J. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655151/ https://www.ncbi.nlm.nih.gov/pubmed/36361533 http://dx.doi.org/10.3390/ijms232112736

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