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Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs
A decrease in the miR-124 expression was observed in various epithelial cancers. Like a classical suppressor, miR-124 can inhibit the translation of multiple oncogenic proteins. Epigenetic mechanisms play a significant role in the regulation of miR-124 expression and involve hypermethylation of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655303/ https://www.ncbi.nlm.nih.gov/pubmed/36362406 http://dx.doi.org/10.3390/ijms232113620 |
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author | Braga, Eleonora A. Fridman, Marina V. Burdennyy, Alexey M. Filippova, Elena A. Loginov, Vitaly I. Pronina, Irina V. Dmitriev, Alexey A. Kushlinskii, Nikolay E. |
author_facet | Braga, Eleonora A. Fridman, Marina V. Burdennyy, Alexey M. Filippova, Elena A. Loginov, Vitaly I. Pronina, Irina V. Dmitriev, Alexey A. Kushlinskii, Nikolay E. |
author_sort | Braga, Eleonora A. |
collection | PubMed |
description | A decrease in the miR-124 expression was observed in various epithelial cancers. Like a classical suppressor, miR-124 can inhibit the translation of multiple oncogenic proteins. Epigenetic mechanisms play a significant role in the regulation of miR-124 expression and involve hypermethylation of the MIR-124-1/-2/-3 genes and the effects of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) according to the model of competing endogenous RNAs (ceRNAs). More than 40 interactomes (lncRNA/miR-124/mRNA) based on competition between lncRNAs and mRNAs for miR-124 binding have been identified in various epithelial cancers. LncRNAs MALAT1, NEAT1, HOXA11-AS, and XIST are the most represented in these axes. Fourteen axes (e.g., SND1-IT1/miR-124/COL4A1) are involved in EMT and/or metastasis. Moreover, eight axes (e.g., OIP5-AS1/miR-124-5p/IDH2) are involved in key pathways, such as Wnt/b-catenin, E2F1, TGF-β, SMAD, ERK/MAPK, HIF-1α, Notch, PI3K/Akt signaling, and cancer cell stemness. Additionally, 15 axes impaired patient survival and three axes reduced chemo- or radiosensitivity. To date, 14 cases of miR-124 regulation by circRNAs have been identified. Half of them involve circHIPK3, which belongs to the exonic ecircRNAs and stimulates cell proliferation, EMT, autophagy, angiogenesis, and multidrug resistance. Thus, miR-124 and its interacting partners may be considered promising targets for cancer therapy. |
format | Online Article Text |
id | pubmed-9655303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96553032022-11-15 Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs Braga, Eleonora A. Fridman, Marina V. Burdennyy, Alexey M. Filippova, Elena A. Loginov, Vitaly I. Pronina, Irina V. Dmitriev, Alexey A. Kushlinskii, Nikolay E. Int J Mol Sci Review A decrease in the miR-124 expression was observed in various epithelial cancers. Like a classical suppressor, miR-124 can inhibit the translation of multiple oncogenic proteins. Epigenetic mechanisms play a significant role in the regulation of miR-124 expression and involve hypermethylation of the MIR-124-1/-2/-3 genes and the effects of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) according to the model of competing endogenous RNAs (ceRNAs). More than 40 interactomes (lncRNA/miR-124/mRNA) based on competition between lncRNAs and mRNAs for miR-124 binding have been identified in various epithelial cancers. LncRNAs MALAT1, NEAT1, HOXA11-AS, and XIST are the most represented in these axes. Fourteen axes (e.g., SND1-IT1/miR-124/COL4A1) are involved in EMT and/or metastasis. Moreover, eight axes (e.g., OIP5-AS1/miR-124-5p/IDH2) are involved in key pathways, such as Wnt/b-catenin, E2F1, TGF-β, SMAD, ERK/MAPK, HIF-1α, Notch, PI3K/Akt signaling, and cancer cell stemness. Additionally, 15 axes impaired patient survival and three axes reduced chemo- or radiosensitivity. To date, 14 cases of miR-124 regulation by circRNAs have been identified. Half of them involve circHIPK3, which belongs to the exonic ecircRNAs and stimulates cell proliferation, EMT, autophagy, angiogenesis, and multidrug resistance. Thus, miR-124 and its interacting partners may be considered promising targets for cancer therapy. MDPI 2022-11-07 /pmc/articles/PMC9655303/ /pubmed/36362406 http://dx.doi.org/10.3390/ijms232113620 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Braga, Eleonora A. Fridman, Marina V. Burdennyy, Alexey M. Filippova, Elena A. Loginov, Vitaly I. Pronina, Irina V. Dmitriev, Alexey A. Kushlinskii, Nikolay E. Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title | Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title_full | Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title_fullStr | Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title_full_unstemmed | Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title_short | Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs |
title_sort | regulation of the key epithelial cancer suppressor mir-124 function by competing endogenous rnas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655303/ https://www.ncbi.nlm.nih.gov/pubmed/36362406 http://dx.doi.org/10.3390/ijms232113620 |
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