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Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study

Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study...

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Autores principales: Jedi, Farzaneh, Dethlefs, Gero, Hauser, Till-Karsten, Hennersdorf, Florian, Mengel, Annerose, Ernemann, Ulrike, Bender, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655339/
https://www.ncbi.nlm.nih.gov/pubmed/36362608
http://dx.doi.org/10.3390/jcm11216381
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author Jedi, Farzaneh
Dethlefs, Gero
Hauser, Till-Karsten
Hennersdorf, Florian
Mengel, Annerose
Ernemann, Ulrike
Bender, Benjamin
author_facet Jedi, Farzaneh
Dethlefs, Gero
Hauser, Till-Karsten
Hennersdorf, Florian
Mengel, Annerose
Ernemann, Ulrike
Bender, Benjamin
author_sort Jedi, Farzaneh
collection PubMed
description Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study of patients with CVST, who underwent MT between 2011 and 2019, was performed looking at procedure success rate and clinical outcomes. Two raters evaluated the cerebral venous system of every patient before and after the intervention using the following scoring system: (0) No obvious thrombosis; (1) thrombosis without impaired blood flow; (2) thrombosis with impaired blood flow; (3) and thrombosis with complete vascular occlusion. The success of MT was measured using a score quotient (Q = A/B), dividing the sum of the patient’s scores after the intervention (A) by the sum of scores before the intervention (B). Overall, 21 MTs were performed on 20 patients with refractory or severe CVST. Clinical improvement was seen in 61.9% during hospital stay and in 80% at 6-month follow-up, with complete recovery in 70% of patients. Patients with favorable outcomes had significantly lower recanalization quotients (p = 0.008). Our study provides evidence supporting that MT may be a safe and effective treatment with favorable clinical outcomes for selected patients with CVST.
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spelling pubmed-96553392022-11-15 Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study Jedi, Farzaneh Dethlefs, Gero Hauser, Till-Karsten Hennersdorf, Florian Mengel, Annerose Ernemann, Ulrike Bender, Benjamin J Clin Med Article Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study of patients with CVST, who underwent MT between 2011 and 2019, was performed looking at procedure success rate and clinical outcomes. Two raters evaluated the cerebral venous system of every patient before and after the intervention using the following scoring system: (0) No obvious thrombosis; (1) thrombosis without impaired blood flow; (2) thrombosis with impaired blood flow; (3) and thrombosis with complete vascular occlusion. The success of MT was measured using a score quotient (Q = A/B), dividing the sum of the patient’s scores after the intervention (A) by the sum of scores before the intervention (B). Overall, 21 MTs were performed on 20 patients with refractory or severe CVST. Clinical improvement was seen in 61.9% during hospital stay and in 80% at 6-month follow-up, with complete recovery in 70% of patients. Patients with favorable outcomes had significantly lower recanalization quotients (p = 0.008). Our study provides evidence supporting that MT may be a safe and effective treatment with favorable clinical outcomes for selected patients with CVST. MDPI 2022-10-28 /pmc/articles/PMC9655339/ /pubmed/36362608 http://dx.doi.org/10.3390/jcm11216381 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jedi, Farzaneh
Dethlefs, Gero
Hauser, Till-Karsten
Hennersdorf, Florian
Mengel, Annerose
Ernemann, Ulrike
Bender, Benjamin
Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title_full Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title_fullStr Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title_full_unstemmed Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title_short Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
title_sort mechanical thrombectomy in cerebral venous sinus thrombosis: reports of a retrospective single-center study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655339/
https://www.ncbi.nlm.nih.gov/pubmed/36362608
http://dx.doi.org/10.3390/jcm11216381
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