Cargando…

PD-L1 Expression in High-Risk Early-Stage Colorectal Cancer—Its Clinical and Biological Significance in Immune Microenvironment

Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that can regulate immune responses in the tumor microenvironment (TME); however, the clinical applications of PD-L1 in early-stage colorectal cancer (CRC) remain unclear. In this study, we aimed to investigate the relationship betwee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Bing-Syuan, Liao, I-Chuang, Lin, Peng-Chan, Wu, Shang-Yin, Kang, Jui-Wen, Lin, Bo-Wen, Chen, Po-Chuan, Chan, Ren-Hao, Lee, Chung-Ta, Shen, Meng-Ru, Chen, Shang-Hung, Yeh, Yu-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655444/ https://www.ncbi.nlm.nih.gov/pubmed/36362062 http://dx.doi.org/10.3390/ijms232113277

Ejemplares similares

Treatment monitoring of colorectal cancer by integrated analysis of plasma concentration and sequencing of circulating tumor DNA
por: Yeh, Yu-Min, et al.
Publicado: (2020)

Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance
por: Yeh, Yu-Min, et al.
Publicado: (2019)

A Prediction Model for Tumor Recurrence in Stage II–III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling
por: Chen, Po-Chuan, et al.
Publicado: (2022)

Clinical Utility of a Cell-Free DNA Assay in Patients With Colorectal Cancer
por: Chan, Ren-Hao, et al.
Publicado: (2021)

Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer
por: Huang, Yi-Hsuan, et al.
Publicado: (2021)

The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer
por: Chan, Ren-Hao, et al.
Publicado: (2022)

Intratumor Heterogeneity of MYO18A and FBXW7 Variants Impact the Clinical Outcome of Stage III Colorectal Cancer
por: Lin, Peng-Chan, et al.
Publicado: (2020)

TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis
por: Chan, Ya-Ling, et al.
Publicado: (2020)

CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer
por: Hsieh, Chi-Che, et al.
Publicado: (2022)

Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy
por: Lin, Peng-Chan, et al.
Publicado: (2021)

Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity—From Case Report to Mouse Model Validation
por: Liu, Shin-Yi, et al.
Publicado: (2019)

Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival
por: Lee, Chung-Ta, et al.
Publicado: (2017)

Adjusted CT Image-Based Radiomic Features Combined with Immune Genomic Expression Achieve Accurate Prognostic Classification and Identification of Therapeutic Targets in Stage III Colorectal Cancer
por: Huang, Yi-Ching, et al.
Publicado: (2022)

Long-Term Usage of Proton Pump Inhibitors Associated with Prognosis in Patients with Colorectal Cancer
por: Wu, Chin-Chia, et al.
Publicado: (2023)

Midostaurin Modulates Tumor Microenvironment and Enhances Efficacy of Anti-PD-1 against Colon Cancer
por: Lai, Cheng-Ta, et al.
Publicado: (2022)

Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition
por: Huang, Yu-Chuan, et al.
Publicado: (2016)

Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy
por: Chang, Chiung-Chih, et al.
Publicado: (2012)

Identification of nodal micrometastasis in colorectal cancer using deep learning on annotation-free whole-slide images
por: Chuang, Wen-Yu, et al.
Publicado: (2021)

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis
por: Wang, Ting, et al.
Publicado: (2023)

Significant Overexpression of DVL1 in Taiwanese Colorectal Cancer Patients with Liver Metastasis
por: Huang, Ming-Yii, et al.
Publicado: (2013)

An Innovative Wearable Device For Monitoring Continuous Body Surface Temperature (HEARThermo): Instrument Validation Study
por: Yeh, Chun-Yin, et al.
Publicado: (2021)

Emergence of RAS mutations in patients with metastatic colorectal cancer receiving cetuximab-based treatment: a study protocol
por: Chen, Shang-Hung, et al.
Publicado: (2019)

Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer
por: Ling, Hang Huong, et al.
Publicado: (2019)

The E3 ubiquitin ligases regulate PD-1/PD-L1 protein levels in tumor microenvironment to improve immunotherapy
por: Hou, Bo, et al.
Publicado: (2023)

SHP-1 is a target of regorafenib in colorectal cancer
por: Fan, Li-Ching, et al.
Publicado: (2014)

Significant perioperative parameters affecting postoperative complications within 30 days following craniotomy for primary malignant brain tumors
por: Yang, Yao-Chung, et al.
Publicado: (2023)

Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
por: Wu, Chin-Chia, et al.
Publicado: (2021)

Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange
por: Chien, Chih-Ta Henry, et al.
Publicado: (2017)

Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer
por: Chen, Qiong-Yuan, et al.
Publicado: (2021)

Continuous temperature monitoring by a wearable device for early detection of febrile events in the SARS-CoV-2 outbreak in Taiwan, 2020
por: Chung, Yi-Ting, et al.
Publicado: (2020)

Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment
por: Väyrynen, Juha P, et al.
Publicado: (2021)

Serum Sickness-Like Reactions After Pneumococcal Vaccination
por: Chung, Bing-Syuan, et al.
Publicado: (2021)

Curcumin Enhances the Abscopal Effect in Mice with Colorectal Cancer by Acting as an Immunomodulator
por: Shih, Kuang-Chung, et al.
Publicado: (2023)

Effects of Dantrolene on Arrhythmogenicity in Isolated Regional Ischemia-Reperfusion Rabbit Hearts with or without Pacing-Induced Heart Failure
por: Chou, Chung-Chuan, et al.
Publicado: (2015)

Parameters of Iliopsoas Plane Immediately Caudal to the Indirect Tendon of Rectus Femoris in Axial Plane Measured on Magnetic Resonance Images in an Adult Eastern Asian Population
por: Yeoh, Shang-Ru, et al.
Publicado: (2022)

Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses
por: Lin, Peng-Chan, et al.
Publicado: (2016)

Role of Sarcoplasmic Reticulum Calcium in Development of Secondary Calcium Rise and Early Afterdepolarizations in Long QT Syndrome Rabbit Model
por: Chang, Po-Cheng, et al.
Publicado: (2015)

A Single Center Observational Study of Spirometry Assessments in Children with Congenital Heart Disease after Surgery
por: Lin, Chien-Heng, et al.
Publicado: (2023)

Pericapsular Nerve Group Block and Iliopsoas Plane Block: A Scoping Review of Quadriceps Weakness after Two Proclaimed Motor-Sparing Hip Blocks
por: Yeoh, Shang-Ru, et al.
Publicado: (2022)

Correction: Yeoh et al. Pericapsular Nerve Group Block and Iliopsoas Plane Block: A Scoping Review of Quadriceps Weakness after Two Proclaimed Motor-Sparing Hip Blocks. Healthcare 2022, 10, 1565
por: Yeoh, Shang-Ru, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3aiksp9h0jr2nntdtgrg1lpl3k