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Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan
The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only ente...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655464/ https://www.ncbi.nlm.nih.gov/pubmed/36361483 http://dx.doi.org/10.3390/ijerph192114603 |
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author | Koigeldinova, Sholpan Alexeyev, Alexey Zharylkassyn, Zhengisbek Otarov, Yertay Omarkulov, Bauyrzhan Tilemissov, Magzhan Ismailov, Chingiz |
author_facet | Koigeldinova, Sholpan Alexeyev, Alexey Zharylkassyn, Zhengisbek Otarov, Yertay Omarkulov, Bauyrzhan Tilemissov, Magzhan Ismailov, Chingiz |
author_sort | Koigeldinova, Sholpan |
collection | PubMed |
description | The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only enterprise dealing with the extraction and beneficiation of chrysotile ores in Kazakhstan. Indicants of cell immunity were detected by flow cytometry; IgA, IgM, and IgG were detected by a multiplex immunological assay. It was found that, among workers impacted by chrysotile asbestos for more than 15 years, compared with individuals who were not impacted by asbestos dust, the level of CD3+ T-cells was decreased (t = −8.76, p < 0.001), as well as the number of CD4+ T-cells (U = 1246.0, p < 0.001). Moreover, CD8+ T-cells increased (t = 5.308, p = 0.001), and neutrophil phagocytic activity also increased, by 1.2 times (U = 305.5, p < 0.001). It was found that working under the condition of professional contact with chrysotile asbestos dust modifies the indicants of humoral immunity, IgA, IgM, and IgG, to a lesser extent than those of cellular immunity. |
format | Online Article Text |
id | pubmed-9655464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96554642022-11-15 Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan Koigeldinova, Sholpan Alexeyev, Alexey Zharylkassyn, Zhengisbek Otarov, Yertay Omarkulov, Bauyrzhan Tilemissov, Magzhan Ismailov, Chingiz Int J Environ Res Public Health Article The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only enterprise dealing with the extraction and beneficiation of chrysotile ores in Kazakhstan. Indicants of cell immunity were detected by flow cytometry; IgA, IgM, and IgG were detected by a multiplex immunological assay. It was found that, among workers impacted by chrysotile asbestos for more than 15 years, compared with individuals who were not impacted by asbestos dust, the level of CD3+ T-cells was decreased (t = −8.76, p < 0.001), as well as the number of CD4+ T-cells (U = 1246.0, p < 0.001). Moreover, CD8+ T-cells increased (t = 5.308, p = 0.001), and neutrophil phagocytic activity also increased, by 1.2 times (U = 305.5, p < 0.001). It was found that working under the condition of professional contact with chrysotile asbestos dust modifies the indicants of humoral immunity, IgA, IgM, and IgG, to a lesser extent than those of cellular immunity. MDPI 2022-11-07 /pmc/articles/PMC9655464/ /pubmed/36361483 http://dx.doi.org/10.3390/ijerph192114603 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Koigeldinova, Sholpan Alexeyev, Alexey Zharylkassyn, Zhengisbek Otarov, Yertay Omarkulov, Bauyrzhan Tilemissov, Magzhan Ismailov, Chingiz Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title | Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title_full | Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title_fullStr | Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title_full_unstemmed | Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title_short | Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan |
title_sort | immune status of workers with professional risk of being affected by chrysotile asbestos in kazakhstan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655464/ https://www.ncbi.nlm.nih.gov/pubmed/36361483 http://dx.doi.org/10.3390/ijerph192114603 |
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