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Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study

Bovine colostrum (BC) has anti-inflammatory, anti-infective, growth and intestinal repair factors that may be beneficial in Crohn’s disease (CD). We assessed whether daily BC for up to 3 months was acceptable to children and young people (CYP) with CD in remission or of mild/moderate severity. CYP w...

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Autores principales: Allen, Stephen J., Belnour, Salma, Renji, Elizabeth, Carter, Bernie, Bray, Lucy, Allen, Angela, Jones, Emma, Urban, Britta, Moule, Sarah, Wang, Duolao, Playford, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655551/
https://www.ncbi.nlm.nih.gov/pubmed/36364868
http://dx.doi.org/10.3390/nu14214598
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author Allen, Stephen J.
Belnour, Salma
Renji, Elizabeth
Carter, Bernie
Bray, Lucy
Allen, Angela
Jones, Emma
Urban, Britta
Moule, Sarah
Wang, Duolao
Playford, Raymond J.
author_facet Allen, Stephen J.
Belnour, Salma
Renji, Elizabeth
Carter, Bernie
Bray, Lucy
Allen, Angela
Jones, Emma
Urban, Britta
Moule, Sarah
Wang, Duolao
Playford, Raymond J.
author_sort Allen, Stephen J.
collection PubMed
description Bovine colostrum (BC) has anti-inflammatory, anti-infective, growth and intestinal repair factors that may be beneficial in Crohn’s disease (CD). We assessed whether daily BC for up to 3 months was acceptable to children and young people (CYP) with CD in remission or of mild/moderate severity. CYP were randomised to receive either BC or matching placebo milk daily for 6 weeks (blinded phase); all received BC for the following 6 weeks (open phase). In 23 CYP, median (inter-quartile range) age was 15.2 (13.9–16.1) years and 9 (39.1%) were girls. A similar proportion of CYP in the BC and placebo arms completed the blinded phase (8/12, 75.0% and 9/11, 81.8% respectively). Twelve (70.6%) CYP completed the open phase with 7 (58.3%) tolerating BC for 3 months. Diaries in weeks 2, 6 and 12 revealed that most CYP took BC every day (5/7, 71.4%; 5/8, 62.5% and 6/11, 54.5% respectively). In interviews, opinions were divided as to preference of BC over the placebo milk and some preferred BC over other nutritional supplements. Symptoms, clinical and laboratory variables and quality of life were similar in the two arms. BC may be an acceptable nutritional supplement for daily, longer-term use in CYP with CD.
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spelling pubmed-96555512022-11-15 Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study Allen, Stephen J. Belnour, Salma Renji, Elizabeth Carter, Bernie Bray, Lucy Allen, Angela Jones, Emma Urban, Britta Moule, Sarah Wang, Duolao Playford, Raymond J. Nutrients Article Bovine colostrum (BC) has anti-inflammatory, anti-infective, growth and intestinal repair factors that may be beneficial in Crohn’s disease (CD). We assessed whether daily BC for up to 3 months was acceptable to children and young people (CYP) with CD in remission or of mild/moderate severity. CYP were randomised to receive either BC or matching placebo milk daily for 6 weeks (blinded phase); all received BC for the following 6 weeks (open phase). In 23 CYP, median (inter-quartile range) age was 15.2 (13.9–16.1) years and 9 (39.1%) were girls. A similar proportion of CYP in the BC and placebo arms completed the blinded phase (8/12, 75.0% and 9/11, 81.8% respectively). Twelve (70.6%) CYP completed the open phase with 7 (58.3%) tolerating BC for 3 months. Diaries in weeks 2, 6 and 12 revealed that most CYP took BC every day (5/7, 71.4%; 5/8, 62.5% and 6/11, 54.5% respectively). In interviews, opinions were divided as to preference of BC over the placebo milk and some preferred BC over other nutritional supplements. Symptoms, clinical and laboratory variables and quality of life were similar in the two arms. BC may be an acceptable nutritional supplement for daily, longer-term use in CYP with CD. MDPI 2022-11-01 /pmc/articles/PMC9655551/ /pubmed/36364868 http://dx.doi.org/10.3390/nu14214598 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Allen, Stephen J.
Belnour, Salma
Renji, Elizabeth
Carter, Bernie
Bray, Lucy
Allen, Angela
Jones, Emma
Urban, Britta
Moule, Sarah
Wang, Duolao
Playford, Raymond J.
Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title_full Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title_fullStr Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title_full_unstemmed Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title_short Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study
title_sort dietary therapy to improve nutrition and gut health in paediatric crohn’s disease; a feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655551/
https://www.ncbi.nlm.nih.gov/pubmed/36364868
http://dx.doi.org/10.3390/nu14214598
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