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Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism

In humans, most free tryptophan is degraded via kynurenine pathways into kynurenines. Kynurenines modulate the immune system, central nervous system, and skeletal muscle bioenergetics. Consequently, kynurenine pathway metabolites (KPMs) have been studied in the context of exercise. However, the effe...

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Autores principales: Mieszkowski, Jan, Brzezińska, Paulina, Stankiewicz, Błażej, Kochanowicz, Andrzej, Niespodziński, Bartłomiej, Reczkowicz, Joanna, Waldziński, Tomasz, Kacprzak, Bartłomiej, Siuba-Jarosz, Natalia, Petr, Miroslav, Antosiewicz, Jędrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655671/
https://www.ncbi.nlm.nih.gov/pubmed/36364748
http://dx.doi.org/10.3390/nu14214485
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author Mieszkowski, Jan
Brzezińska, Paulina
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Reczkowicz, Joanna
Waldziński, Tomasz
Kacprzak, Bartłomiej
Siuba-Jarosz, Natalia
Petr, Miroslav
Antosiewicz, Jędrzej
author_facet Mieszkowski, Jan
Brzezińska, Paulina
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Reczkowicz, Joanna
Waldziński, Tomasz
Kacprzak, Bartłomiej
Siuba-Jarosz, Natalia
Petr, Miroslav
Antosiewicz, Jędrzej
author_sort Mieszkowski, Jan
collection PubMed
description In humans, most free tryptophan is degraded via kynurenine pathways into kynurenines. Kynurenines modulate the immune system, central nervous system, and skeletal muscle bioenergetics. Consequently, kynurenine pathway metabolites (KPMs) have been studied in the context of exercise. However, the effect of vitamin D supplementation on exercise-induced changes in KPMs has not been investigated. Here, we analyzed the effect of a single high-dose vitamin D supplementation on KPMs and tryptophan levels in runners after an ultramarathon. In the study, 35 amateur runners were assigned into two groups: vitamin D supplementation group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run (n = 16); and control (placebo) group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Kynurenic, xanthurenic, quinolinic, and picolinic acids levels were significantly increased after the run in the control group, but the effect was blunted by vitamin D supplementation. Conversely, the decrease in serum tryptophan, tyrosine, and phenylalanine levels immediately after the run was more pronounced in the supplemented group than in the control. The 3-hydroxy-l-kynurenine levels were significantly increased in both groups after the run. We conclude that vitamin D supplementation affects ultramarathon-induced changes in tryptophan metabolism.
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spelling pubmed-96556712022-11-15 Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism Mieszkowski, Jan Brzezińska, Paulina Stankiewicz, Błażej Kochanowicz, Andrzej Niespodziński, Bartłomiej Reczkowicz, Joanna Waldziński, Tomasz Kacprzak, Bartłomiej Siuba-Jarosz, Natalia Petr, Miroslav Antosiewicz, Jędrzej Nutrients Article In humans, most free tryptophan is degraded via kynurenine pathways into kynurenines. Kynurenines modulate the immune system, central nervous system, and skeletal muscle bioenergetics. Consequently, kynurenine pathway metabolites (KPMs) have been studied in the context of exercise. However, the effect of vitamin D supplementation on exercise-induced changes in KPMs has not been investigated. Here, we analyzed the effect of a single high-dose vitamin D supplementation on KPMs and tryptophan levels in runners after an ultramarathon. In the study, 35 amateur runners were assigned into two groups: vitamin D supplementation group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run (n = 16); and control (placebo) group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Kynurenic, xanthurenic, quinolinic, and picolinic acids levels were significantly increased after the run in the control group, but the effect was blunted by vitamin D supplementation. Conversely, the decrease in serum tryptophan, tyrosine, and phenylalanine levels immediately after the run was more pronounced in the supplemented group than in the control. The 3-hydroxy-l-kynurenine levels were significantly increased in both groups after the run. We conclude that vitamin D supplementation affects ultramarathon-induced changes in tryptophan metabolism. MDPI 2022-10-25 /pmc/articles/PMC9655671/ /pubmed/36364748 http://dx.doi.org/10.3390/nu14214485 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mieszkowski, Jan
Brzezińska, Paulina
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Reczkowicz, Joanna
Waldziński, Tomasz
Kacprzak, Bartłomiej
Siuba-Jarosz, Natalia
Petr, Miroslav
Antosiewicz, Jędrzej
Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title_full Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title_fullStr Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title_full_unstemmed Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title_short Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism
title_sort direct effects of vitamin d supplementation on ultramarathon-induced changes in kynurenine metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655671/
https://www.ncbi.nlm.nih.gov/pubmed/36364748
http://dx.doi.org/10.3390/nu14214485
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