Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Recessive Stargardt disease (STGD1) is an inherited retinopathy caused by mutations in the ABCA4 gene. The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (RPE) cells. Here, we show that RPE cells deri...

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Detalles Bibliográficos
Autores principales: Ng, Eunice Sze Yin, Kady, Nermin, Hu, Jane, Dave, Arpita, Jiang, Zhichun, Pei, Jacqueline, Gorin, Michael B., Matynia, Anna, Radu, Roxana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655712/
https://www.ncbi.nlm.nih.gov/pubmed/36359858
http://dx.doi.org/10.3390/cells11213462

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