Cargando…
A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice
Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed a data-driven behavioural stratification together with single-ce...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655779/ https://www.ncbi.nlm.nih.gov/pubmed/36359800 http://dx.doi.org/10.3390/cells11213405 |
_version_ | 1784829270235807744 |
---|---|
author | Vennin, Constance Hewel, Charlotte Todorov, Hristo Wendelmuth, Marlon Radyushkin, Konstantin Heimbach, André Horenko, Illia Ayash, Sarah Müller, Marianne B. Schweiger, Susann Gerber, Susanne Lutz, Beat |
author_facet | Vennin, Constance Hewel, Charlotte Todorov, Hristo Wendelmuth, Marlon Radyushkin, Konstantin Heimbach, André Horenko, Illia Ayash, Sarah Müller, Marianne B. Schweiger, Susann Gerber, Susanne Lutz, Beat |
author_sort | Vennin, Constance |
collection | PubMed |
description | Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed a data-driven behavioural stratification together with single-cell transcriptomics of the hippocampus in a mouse model of chronic social defeat stress. Our work revealed that in a sub-group exhibiting molecular responses upon chronic stress, the dorsal hippocampus is particularly involved in neuroimmune responses, angiogenesis, myelination, and neurogenesis, thereby enabling brain restoration and homeostasis after chronic stress. Based on these molecular insights, we applied rapamycin after the stress as a proof-of-concept pharmacological intervention and were able to substantially increase stress resilience. Our findings serve as a data resource and can open new avenues for further understanding of molecular processes underlying stress response and for targeted interventions supporting resilience. |
format | Online Article Text |
id | pubmed-9655779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96557792022-11-15 A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice Vennin, Constance Hewel, Charlotte Todorov, Hristo Wendelmuth, Marlon Radyushkin, Konstantin Heimbach, André Horenko, Illia Ayash, Sarah Müller, Marianne B. Schweiger, Susann Gerber, Susanne Lutz, Beat Cells Article Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed a data-driven behavioural stratification together with single-cell transcriptomics of the hippocampus in a mouse model of chronic social defeat stress. Our work revealed that in a sub-group exhibiting molecular responses upon chronic stress, the dorsal hippocampus is particularly involved in neuroimmune responses, angiogenesis, myelination, and neurogenesis, thereby enabling brain restoration and homeostasis after chronic stress. Based on these molecular insights, we applied rapamycin after the stress as a proof-of-concept pharmacological intervention and were able to substantially increase stress resilience. Our findings serve as a data resource and can open new avenues for further understanding of molecular processes underlying stress response and for targeted interventions supporting resilience. MDPI 2022-10-27 /pmc/articles/PMC9655779/ /pubmed/36359800 http://dx.doi.org/10.3390/cells11213405 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vennin, Constance Hewel, Charlotte Todorov, Hristo Wendelmuth, Marlon Radyushkin, Konstantin Heimbach, André Horenko, Illia Ayash, Sarah Müller, Marianne B. Schweiger, Susann Gerber, Susanne Lutz, Beat A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title | A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title_full | A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title_fullStr | A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title_full_unstemmed | A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title_short | A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice |
title_sort | resilience related glial-neurovascular network is transcriptionally activated after chronic social defeat in male mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655779/ https://www.ncbi.nlm.nih.gov/pubmed/36359800 http://dx.doi.org/10.3390/cells11213405 |
work_keys_str_mv | AT venninconstance aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT hewelcharlotte aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT todorovhristo aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT wendelmuthmarlon aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT radyushkinkonstantin aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT heimbachandre aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT horenkoillia aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT ayashsarah aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT mullermarianneb aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT schweigersusann aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT gerbersusanne aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT lutzbeat aresiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT venninconstance resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT hewelcharlotte resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT todorovhristo resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT wendelmuthmarlon resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT radyushkinkonstantin resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT heimbachandre resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT horenkoillia resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT ayashsarah resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT mullermarianneb resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT schweigersusann resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT gerbersusanne resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice AT lutzbeat resiliencerelatedglialneurovascularnetworkistranscriptionallyactivatedafterchronicsocialdefeatinmalemice |