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Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique
This study aimed to modify EndoREZ with 2.5% dimethylaminododecyl methacrylate (DMADDM) and 1% magnetic nanoparticles (MNP) to study its sealing property, penetration and long-term antibacterial and therapeutic effect in the single-cone technique (SCT) compared with EndoREZ and iRoot SP. Thirty sing...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655841/ https://www.ncbi.nlm.nih.gov/pubmed/36364498 http://dx.doi.org/10.3390/nano12213722 |
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author | Fan, Yu Wang, Zheng Sun, Yan Guo, Xiao Wang, Haohao Xu, Hockin H. K. Wang, Suping Zhou, Xuedong Li, Bolei Cheng, Lei |
author_facet | Fan, Yu Wang, Zheng Sun, Yan Guo, Xiao Wang, Haohao Xu, Hockin H. K. Wang, Suping Zhou, Xuedong Li, Bolei Cheng, Lei |
author_sort | Fan, Yu |
collection | PubMed |
description | This study aimed to modify EndoREZ with 2.5% dimethylaminododecyl methacrylate (DMADDM) and 1% magnetic nanoparticles (MNP) to study its sealing property, penetration and long-term antibacterial and therapeutic effect in the single-cone technique (SCT) compared with EndoREZ and iRoot SP. Thirty single-root human maxillary premolars were assigned into three groups and obturated with three different root canal sealers by SCT. Every specimen was then scanned using micro-CT to analyze void fraction, and void volumes and confocal laser scanning microscope (CLSM) was used to study the dentin penetration. The long-term antimicrobial effects were tested in vitro before and after aging 1 and 4 weeks by the single-strain Enterococcus faecalis biofilm model. In addition, the beagle canine model of apical periodontitis (AP) was utilized to judge and compare the therapeutic effect of three sealers in SCT. The void fraction and void volumes of the modified root canal sealer were not significantly different from iRoot SP (p > 0.05) but were lower than EndoREZ (p < 0.05). The modified root canal sealant displayed a greater penetration, long-term antibacterial property, and treatment effect than the other groups (p < 0.05). This indicated that after being modified with DMADDM and MNP, it showed better performance in SCT. |
format | Online Article Text |
id | pubmed-9655841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96558412022-11-15 Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique Fan, Yu Wang, Zheng Sun, Yan Guo, Xiao Wang, Haohao Xu, Hockin H. K. Wang, Suping Zhou, Xuedong Li, Bolei Cheng, Lei Nanomaterials (Basel) Article This study aimed to modify EndoREZ with 2.5% dimethylaminododecyl methacrylate (DMADDM) and 1% magnetic nanoparticles (MNP) to study its sealing property, penetration and long-term antibacterial and therapeutic effect in the single-cone technique (SCT) compared with EndoREZ and iRoot SP. Thirty single-root human maxillary premolars were assigned into three groups and obturated with three different root canal sealers by SCT. Every specimen was then scanned using micro-CT to analyze void fraction, and void volumes and confocal laser scanning microscope (CLSM) was used to study the dentin penetration. The long-term antimicrobial effects were tested in vitro before and after aging 1 and 4 weeks by the single-strain Enterococcus faecalis biofilm model. In addition, the beagle canine model of apical periodontitis (AP) was utilized to judge and compare the therapeutic effect of three sealers in SCT. The void fraction and void volumes of the modified root canal sealer were not significantly different from iRoot SP (p > 0.05) but were lower than EndoREZ (p < 0.05). The modified root canal sealant displayed a greater penetration, long-term antibacterial property, and treatment effect than the other groups (p < 0.05). This indicated that after being modified with DMADDM and MNP, it showed better performance in SCT. MDPI 2022-10-23 /pmc/articles/PMC9655841/ /pubmed/36364498 http://dx.doi.org/10.3390/nano12213722 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fan, Yu Wang, Zheng Sun, Yan Guo, Xiao Wang, Haohao Xu, Hockin H. K. Wang, Suping Zhou, Xuedong Li, Bolei Cheng, Lei Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title | Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title_full | Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title_fullStr | Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title_full_unstemmed | Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title_short | Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique |
title_sort | effect of the modified methacrylate-based root canal sealer in single-cone technique |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655841/ https://www.ncbi.nlm.nih.gov/pubmed/36364498 http://dx.doi.org/10.3390/nano12213722 |
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