Cargando…

Rapid Reversible Osmoregulation of Cytoplasmic Biomolecular Condensates of Human Interferon-α-Induced Antiviral MxA GTPase

We previously discovered that exogenously expressed GFP-tagged cytoplasmic human myxovirus resistance protein (MxA), a major antiviral effector of Type I and III interferons (IFNs) against several RNA- and DNA-containing viruses, existed in the cytoplasm in phase-separated membraneless biomolecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sehgal, Pravin B., Yuan, Huijuan, Jin, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655878/ https://www.ncbi.nlm.nih.gov/pubmed/36361529 http://dx.doi.org/10.3390/ijms232112739

Ejemplares similares

Metastable biomolecular condensates of interferon-inducible antiviral Mx-family GTPases: A paradigm shift in the last three years
por: Sehgal, Pravin B
Publicado: (2021)

Interferon-α-induced cytoplasmic MxA structures in hepatoma Huh7 and primary endothelial cells
por: Davis, Deodate, et al.
Publicado: (2018)

Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA
por: Lorenzo, María M., et al.
Publicado: (2017)

The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein
por: Spiegel, Martin, et al.
Publicado: (2004)

Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV
por: Sehgal, Pravin B., et al.
Publicado: (2021)

MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9)
por: Yuan, Huijuan, et al.
Publicado: (2016)

Biomolecular condensates in cancer cell biology: interleukin-6-induced cytoplasmic and nuclear STAT3/PY-STAT3 condensates in hepatoma cells
por: Sehgal, Pravin B.
Publicado: (2019)

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
por: Hamano, Emi, et al.
Publicado: (2005)

Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection
por: Piri, Ruut, et al.
Publicado: (2020)

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
por: Xiao, Han, et al.
Publicado: (2013)

Detection of new biallelic polymorphisms in the human MxA gene
por: Duc, Tam Tran Thi, et al.
Publicado: (2012)

MxA mRNA Quantification and Disability Progression in Interferon Beta-Treated Multiple Sclerosis Patients
por: Serana, Federico, et al.
Publicado: (2014)

Baseline MxA mRNA Expression Predicts Interferon Beta Response in Multiple Sclerosis Patients
por: Matas, Elisabet, et al.
Publicado: (2014)

MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome
por: Maria, Naomi I, et al.
Publicado: (2014)

Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients
por: He, Mengzhu, et al.
Publicado: (2023)

Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
por: Chen, Yang, et al.
Publicado: (2017)

Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection
por: Zhang, Xiaoai, et al.
Publicado: (2013)

Interleukin-6 at the Host-Tumor Interface: STAT3 in Biomolecular Condensates in Cancer Cells
por: Sehgal, Pravin B.
Publicado: (2022)

Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold
por: Mäkelä, M. J., et al.
Publicado: (1999)

The Curious Case of Type I IFN and MxA: Tipping the Immune Balance in AIDS
por: Furuya, Andrea Kinga Marias, et al.
Publicado: (2014)

Blood MxA protein as a marker for respiratory virus infections in young children
por: Toivonen, Laura, et al.
Publicado: (2015)

MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study
por: Metz, Matthäus, et al.
Publicado: (2023)

Assessment of the Relation Between SNP in MxA Gene and the Responsiveness of Egyptian HCV Genotype 4 Patients to Pegylated Interferon and Ribavirin Treatment
por: Hassany, Mohamed, et al.
Publicado: (2017)

Structural analysis of tumor-related single amino acid mutations in human MxA protein
por: Hu, Jia-Li, et al.
Publicado: (2015)

Classical swine fever virus replicated poorly in cells from MxA transgenic pigs
por: Zhao, Yicheng, et al.
Publicado: (2016)

Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA
por: Ashenberg, Orr, et al.
Publicado: (2017)

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein
por: Deeg, Christoph M., et al.
Publicado: (2017)

Reversible Kinetic Trapping of FUS Biomolecular Condensates
por: Chatterjee, Sayantan, et al.
Publicado: (2021)

SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses
por: Dornfeld, Dominik, et al.
Publicado: (2018)

MxA mRNA decrease preceding NAb detection in IFNβ‐treated MS patients
por: Libertinova, Jana, et al.
Publicado: (2017)

Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China
por: Zheng, Kexi, et al.
Publicado: (2022)

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses
por: Serrero, Manutea C, et al.
Publicado: (2022)

Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon α
por: Zhijian, Yu, et al.
Publicado: (2010)

Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication
por: Alalem, Mai, et al.
Publicado: (2023)

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein
por: Mänz, Benjamin, et al.
Publicado: (2013)

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import
por: Götz, Veronika, et al.
Publicado: (2016)

MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA
por: Kang, Mafei, et al.
Publicado: (2017)

Corrigendum: Influence of IL28B and MxA gene polymorphisms on HCV clearance in Han Chinese population
por: Zang, Feng, et al.
Publicado: (2019)

Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein
por: Fuchs, Jonas, et al.
Publicado: (2020)

The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis
por: Coerver, Eline M. E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kq6njksam051jap78m7f8kjblg