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Polymorph Separation by Ordered Patterning

We herein address the problem of polymorph selection by introducing a general and straightforward concept based on their ordering. We demonstrated the concept by the ordered patterning of four compounds capable of forming different polymorphs when deposited on technologically relevant surfaces. Our...

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Detalles Bibliográficos
Autores principales: Cavallini, Massimiliano, Brucale, Marco, Gentili, Denis, Liscio, Fabiola, Maini, Lucia, Favaretto, Laura, Manet, Ilse, Zambianchi, Massimo, Melucci, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655954/
https://www.ncbi.nlm.nih.gov/pubmed/36364061
http://dx.doi.org/10.3390/molecules27217235
Descripción
Sumario:We herein address the problem of polymorph selection by introducing a general and straightforward concept based on their ordering. We demonstrated the concept by the ordered patterning of four compounds capable of forming different polymorphs when deposited on technologically relevant surfaces. Our approach exploits the fact that, when the growth of a crystalline material is confined within sufficiently small cavities, only one of the possible polymorphs is generated. We verify our method by utilizing several model compounds to fabricate micrometric “logic patterns” in which each of the printed pixels is easily identifiable as comprising only one polymorph and can be individually accessed for further operations.