Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice

Accumulation of α-synuclein (α-syn) is the pathological hallmark of α-synucleinopathy. Rapid eye movement (REM) sleep behavior disorder (RBD) is a pivotal manifestation of α-synucleinopathy including Parkinson’s disease (PD). RBD is clinically confirmed by REM sleep without atonia (RWA) in polysomno...

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Detalles Bibliográficos
Autores principales: Okuda, Shinya, Nakayama, Takeo, Uemura, Norihito, Hikawa, Rie, Ikuno, Masashi, Yamakado, Hodaka, Inoue, Haruhisa, Tachibana, Naoko, Hayashi, Yu, Takahashi, Ryosuke, Egawa, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656146/
https://www.ncbi.nlm.nih.gov/pubmed/36362177
http://dx.doi.org/10.3390/ijms232113390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656146/
https://www.ncbi.nlm.nih.gov/pubmed/36362177
http://dx.doi.org/10.3390/ijms232113390

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