Cargando…

3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments

Rheumatoid arthritis (RA) is one of the most common autoimmune disorders affecting 0.5–1% of the population worldwide. As a disease of multifactorial etiology, its constant study has made it possible to unravel the pathophysiological processes that cause the illness. However, efficient and validated...

Descripción completa

Detalles Bibliográficos
Autores principales: Badillo-Mata, Jessica Andrea, Camacho-Villegas, Tanya Amanda, Lugo-Fabres, Pavel Hayl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656230/
https://www.ncbi.nlm.nih.gov/pubmed/36359806
http://dx.doi.org/10.3390/cells11213410
_version_ 1784829382022397952
author Badillo-Mata, Jessica Andrea
Camacho-Villegas, Tanya Amanda
Lugo-Fabres, Pavel Hayl
author_facet Badillo-Mata, Jessica Andrea
Camacho-Villegas, Tanya Amanda
Lugo-Fabres, Pavel Hayl
author_sort Badillo-Mata, Jessica Andrea
collection PubMed
description Rheumatoid arthritis (RA) is one of the most common autoimmune disorders affecting 0.5–1% of the population worldwide. As a disease of multifactorial etiology, its constant study has made it possible to unravel the pathophysiological processes that cause the illness. However, efficient and validated disease models are necessary to continue the search for new disease-modulating drugs. Technologies, such as 3D cell culture and organ-on-a-chip, have contributed to accelerating the prospecting of new therapeutic molecules and even helping to elucidate hitherto unknown aspects of the pathogenesis of multiple diseases. These technologies, where medicine and biotechnology converge, can be applied to understand RA. This review discusses the critical elements of RA pathophysiology and current treatment strategies. Next, we discuss 3D cell culture and apply these methodologies for rheumatological diseases and selected models for RA. Finally, we summarize the application of 3D cell culture for RA treatment.
format Online
Article
Text
id pubmed-9656230
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96562302022-11-15 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments Badillo-Mata, Jessica Andrea Camacho-Villegas, Tanya Amanda Lugo-Fabres, Pavel Hayl Cells Review Rheumatoid arthritis (RA) is one of the most common autoimmune disorders affecting 0.5–1% of the population worldwide. As a disease of multifactorial etiology, its constant study has made it possible to unravel the pathophysiological processes that cause the illness. However, efficient and validated disease models are necessary to continue the search for new disease-modulating drugs. Technologies, such as 3D cell culture and organ-on-a-chip, have contributed to accelerating the prospecting of new therapeutic molecules and even helping to elucidate hitherto unknown aspects of the pathogenesis of multiple diseases. These technologies, where medicine and biotechnology converge, can be applied to understand RA. This review discusses the critical elements of RA pathophysiology and current treatment strategies. Next, we discuss 3D cell culture and apply these methodologies for rheumatological diseases and selected models for RA. Finally, we summarize the application of 3D cell culture for RA treatment. MDPI 2022-10-28 /pmc/articles/PMC9656230/ /pubmed/36359806 http://dx.doi.org/10.3390/cells11213410 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Badillo-Mata, Jessica Andrea
Camacho-Villegas, Tanya Amanda
Lugo-Fabres, Pavel Hayl
3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title_full 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title_fullStr 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title_full_unstemmed 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title_short 3D Cell Culture as Tools to Characterize Rheumatoid Arthritis Signaling and Development of New Treatments
title_sort 3d cell culture as tools to characterize rheumatoid arthritis signaling and development of new treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656230/
https://www.ncbi.nlm.nih.gov/pubmed/36359806
http://dx.doi.org/10.3390/cells11213410
work_keys_str_mv AT badillomatajessicaandrea 3dcellcultureastoolstocharacterizerheumatoidarthritissignalinganddevelopmentofnewtreatments
AT camachovillegastanyaamanda 3dcellcultureastoolstocharacterizerheumatoidarthritissignalinganddevelopmentofnewtreatments
AT lugofabrespavelhayl 3dcellcultureastoolstocharacterizerheumatoidarthritissignalinganddevelopmentofnewtreatments