The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease

The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant E...

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Detalles Bibliográficos
Autor principal: Harris, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656309/
https://www.ncbi.nlm.nih.gov/pubmed/36359813
http://dx.doi.org/10.3390/cells11213416
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author Harris, Raymond C.
author_facet Harris, Raymond C.
author_sort Harris, Raymond C.
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description The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant EGFR activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease.
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spelling pubmed-96563092022-11-15 The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease Harris, Raymond C. Cells Review The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant EGFR activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease. MDPI 2022-10-28 /pmc/articles/PMC9656309/ /pubmed/36359813 http://dx.doi.org/10.3390/cells11213416 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harris, Raymond C.
The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title_full The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title_fullStr The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title_full_unstemmed The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title_short The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
title_sort role of the epidermal growth factor receptor in diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656309/
https://www.ncbi.nlm.nih.gov/pubmed/36359813
http://dx.doi.org/10.3390/cells11213416
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