Leukocyte Nuclear Morphology Alterations in Dilated Cardiomyopathy Caused by a Lamin AC Truncating Mutation (LMNA/Ser431*) Are Modified by the Presence of a LAP2 Missense Polymorphism (TMPO/Arg690Cys)

The clinical phenotype of LMNA-associated dilated cardiomyopathy (DCM) varies even among individuals who share the same mutation. LMNA encodes lamin AC, which interacts with the lamin-associated protein 2 alpha (LAP2α) encoded by the TMPO gene. The LAP2α/Arg690Cys polymorphism is frequent in Latin A...

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Detalles Bibliográficos
Autores principales: González-Garrido, Antonia, Rosas-Madrigal, Sandra, Rojo-Domínguez, Arturo, Arellanes-Robledo, Jaime, López-Mora, Enrique, Carnevale, Alessandra, Arregui, Leticia, Rosendo-Gutiérrez, Rigoberto, Romero-Hidalgo, Sandra, Villarreal-Molina, María Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656322/
https://www.ncbi.nlm.nih.gov/pubmed/36362411
http://dx.doi.org/10.3390/ijms232113626

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