Cargando…
Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L.
Centella asiatica L., commonly known as Gotu kola, Indian pennywort, and Asiatic pennyworts, is an herbaceous perennial plant that belongs to the family Apiaceae and has long been used in the traditional medicine system. The plant is known to produce a wide range of active metabolites such as triter...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656378/ https://www.ncbi.nlm.nih.gov/pubmed/36365380 http://dx.doi.org/10.3390/plants11212928 |
_version_ | 1784829418743529472 |
---|---|
author | Ganie, Irfan Bashir Ahmad, Zishan Shahzad, Anwar Zaushintsena, Alexandra Neverova, Olga Ivanova, Svetlana Wasi, Adla Tahseen, Sabaha |
author_facet | Ganie, Irfan Bashir Ahmad, Zishan Shahzad, Anwar Zaushintsena, Alexandra Neverova, Olga Ivanova, Svetlana Wasi, Adla Tahseen, Sabaha |
author_sort | Ganie, Irfan Bashir |
collection | PubMed |
description | Centella asiatica L., commonly known as Gotu kola, Indian pennywort, and Asiatic pennyworts, is an herbaceous perennial plant that belongs to the family Apiaceae and has long been used in the traditional medicine system. The plant is known to produce a wide range of active metabolites such as triterpenoids including asiatic acid, asiaticoside, brahmoside, and madecassic acid along with other constituents including centellose, centelloside, and madecassoside, etc., which show immense pharmacological activity. Due to its beneficial role in neuroprotection activity, the plant has been considered as a brain tonic. However, limited cultivation, poor seed viability with low germination rate, and overexploitation for decades have led to severe depletion and threatened its wild stocks. The present review aimed to provide up-to-date information on biotechnological tools applied to this endangered medicinal plant for its in vitro propagation, direct or indirect regeneration, synthetic seed production, strategies for secondary metabolite productions including different elicitors. In addition, a proposed mechanism for the biosynthesis of triterpenoids is also discussed. |
format | Online Article Text |
id | pubmed-9656378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96563782022-11-15 Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. Ganie, Irfan Bashir Ahmad, Zishan Shahzad, Anwar Zaushintsena, Alexandra Neverova, Olga Ivanova, Svetlana Wasi, Adla Tahseen, Sabaha Plants (Basel) Review Centella asiatica L., commonly known as Gotu kola, Indian pennywort, and Asiatic pennyworts, is an herbaceous perennial plant that belongs to the family Apiaceae and has long been used in the traditional medicine system. The plant is known to produce a wide range of active metabolites such as triterpenoids including asiatic acid, asiaticoside, brahmoside, and madecassic acid along with other constituents including centellose, centelloside, and madecassoside, etc., which show immense pharmacological activity. Due to its beneficial role in neuroprotection activity, the plant has been considered as a brain tonic. However, limited cultivation, poor seed viability with low germination rate, and overexploitation for decades have led to severe depletion and threatened its wild stocks. The present review aimed to provide up-to-date information on biotechnological tools applied to this endangered medicinal plant for its in vitro propagation, direct or indirect regeneration, synthetic seed production, strategies for secondary metabolite productions including different elicitors. In addition, a proposed mechanism for the biosynthesis of triterpenoids is also discussed. MDPI 2022-10-30 /pmc/articles/PMC9656378/ /pubmed/36365380 http://dx.doi.org/10.3390/plants11212928 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ganie, Irfan Bashir Ahmad, Zishan Shahzad, Anwar Zaushintsena, Alexandra Neverova, Olga Ivanova, Svetlana Wasi, Adla Tahseen, Sabaha Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title | Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title_full | Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title_fullStr | Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title_full_unstemmed | Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title_short | Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L. |
title_sort | biotechnological intervention and secondary metabolite production in centella asiatica l. |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656378/ https://www.ncbi.nlm.nih.gov/pubmed/36365380 http://dx.doi.org/10.3390/plants11212928 |
work_keys_str_mv | AT ganieirfanbashir biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT ahmadzishan biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT shahzadanwar biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT zaushintsenaalexandra biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT neverovaolga biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT ivanovasvetlana biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT wasiadla biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical AT tahseensabaha biotechnologicalinterventionandsecondarymetaboliteproductionincentellaasiatical |