“One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine

The efficient “One-pot” CuCl(2)-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2′-disulfanediyldianilines by using bifunctional-r...

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Autores principales: Wang, Dehe, Lu, Qichao, Li, Zhanjun, Fang, Chen, Liu, Ran, Yang, Bingchuan, Shen, Guodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656399/
https://www.ncbi.nlm.nih.gov/pubmed/36364217
http://dx.doi.org/10.3390/molecules27217392
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author Wang, Dehe
Lu, Qichao
Li, Zhanjun
Fang, Chen
Liu, Ran
Yang, Bingchuan
Shen, Guodong
author_facet Wang, Dehe
Lu, Qichao
Li, Zhanjun
Fang, Chen
Liu, Ran
Yang, Bingchuan
Shen, Guodong
author_sort Wang, Dehe
collection PubMed
description The efficient “One-pot” CuCl(2)-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2′-disulfanediyldianilines by using bifunctional-reagent N, N′-dimethylethane-1,2-diamine (DMEDA), which worked as ligand and reductant. The reactions were compatible with a range of substrates to give the corresponding products in moderate to excellent yields.
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spelling pubmed-96563992022-11-15 “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine Wang, Dehe Lu, Qichao Li, Zhanjun Fang, Chen Liu, Ran Yang, Bingchuan Shen, Guodong Molecules Article The efficient “One-pot” CuCl(2)-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2′-disulfanediyldianilines by using bifunctional-reagent N, N′-dimethylethane-1,2-diamine (DMEDA), which worked as ligand and reductant. The reactions were compatible with a range of substrates to give the corresponding products in moderate to excellent yields. MDPI 2022-10-31 /pmc/articles/PMC9656399/ /pubmed/36364217 http://dx.doi.org/10.3390/molecules27217392 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Dehe
Lu, Qichao
Li, Zhanjun
Fang, Chen
Liu, Ran
Yang, Bingchuan
Shen, Guodong
“One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title_full “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title_fullStr “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title_full_unstemmed “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title_short “One-Pot” CuCl(2)-Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine
title_sort “one-pot” cucl(2)-mediated condensation/c–s bond coupling reactions to synthesize dibenzothiazepines by bi-functional-reagent n, n′-dimethylethane-1,2-diamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656399/
https://www.ncbi.nlm.nih.gov/pubmed/36364217
http://dx.doi.org/10.3390/molecules27217392
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