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Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease
Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. Studies in Pcsk6-deficient mice have demonstrated the imp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656567/ https://www.ncbi.nlm.nih.gov/pubmed/36362216 http://dx.doi.org/10.3390/ijms232113429 |
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author | Wu, Qingyu Chen, Shenghan |
author_facet | Wu, Qingyu Chen, Shenghan |
author_sort | Wu, Qingyu |
collection | PubMed |
description | Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. Studies in Pcsk6-deficient mice have demonstrated the importance of Pcsk6 in embryonic development, body axis specification, ovarian function, and extracellular matrix remodeling in articular cartilage. In the cardiovascular system, PCSK6 acts as a key modulator in heart formation, lipoprotein metabolism, body fluid homeostasis, cardiac repair, and vascular remodeling. To date, dysregulated PCSK6 expression or function has been implicated in major cardiovascular diseases, including atrial septal defects, hypertension, atherosclerosis, myocardial infarction, and cardiac aging. In this review, we describe biochemical characteristics and posttranslational modifications of PCSK6. Moreover, we discuss the role of PCSK6 and related molecular mechanisms in cardiovascular biology and disease. |
format | Online Article Text |
id | pubmed-9656567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96565672022-11-15 Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease Wu, Qingyu Chen, Shenghan Int J Mol Sci Review Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. Studies in Pcsk6-deficient mice have demonstrated the importance of Pcsk6 in embryonic development, body axis specification, ovarian function, and extracellular matrix remodeling in articular cartilage. In the cardiovascular system, PCSK6 acts as a key modulator in heart formation, lipoprotein metabolism, body fluid homeostasis, cardiac repair, and vascular remodeling. To date, dysregulated PCSK6 expression or function has been implicated in major cardiovascular diseases, including atrial septal defects, hypertension, atherosclerosis, myocardial infarction, and cardiac aging. In this review, we describe biochemical characteristics and posttranslational modifications of PCSK6. Moreover, we discuss the role of PCSK6 and related molecular mechanisms in cardiovascular biology and disease. MDPI 2022-11-03 /pmc/articles/PMC9656567/ /pubmed/36362216 http://dx.doi.org/10.3390/ijms232113429 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wu, Qingyu Chen, Shenghan Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title | Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title_full | Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title_fullStr | Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title_full_unstemmed | Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title_short | Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease |
title_sort | proprotein convertase subtilisin/kexin 6 in cardiovascular biology and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656567/ https://www.ncbi.nlm.nih.gov/pubmed/36362216 http://dx.doi.org/10.3390/ijms232113429 |
work_keys_str_mv | AT wuqingyu proproteinconvertasesubtilisinkexin6incardiovascularbiologyanddisease AT chenshenghan proproteinconvertasesubtilisinkexin6incardiovascularbiologyanddisease |