Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions

Cis-alkenes are ubiquitous in biological molecules, which makes it greatly significant to develop efficient methods toward construction of cis-olefins. Herein, we reported a facile semi-hydrogenation of alkynes to cis-alkenes in an efficient way with cuprous bromide/tributylphosphine as the catalyst...

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Detalles Bibliográficos
Autores principales: Zeng, Yuxi, Zhang, Honggang, Ma, Daofan, Wang, Guangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656742/
https://www.ncbi.nlm.nih.gov/pubmed/36364041
http://dx.doi.org/10.3390/molecules27217213
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author Zeng, Yuxi
Zhang, Honggang
Ma, Daofan
Wang, Guangwei
author_facet Zeng, Yuxi
Zhang, Honggang
Ma, Daofan
Wang, Guangwei
author_sort Zeng, Yuxi
collection PubMed
description Cis-alkenes are ubiquitous in biological molecules, which makes it greatly significant to develop efficient methods toward construction of cis-olefins. Herein, we reported a facile semi-hydrogenation of alkynes to cis-alkenes in an efficient way with cuprous bromide/tributylphosphine as the catalyst and bis(pinacolato)diboron/methanol as the hydrogen donor. The method features convenient and facile reaction conditions, wide substrate scope, high yields, and high stereoselectivity.
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spelling pubmed-96567422022-11-15 Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions Zeng, Yuxi Zhang, Honggang Ma, Daofan Wang, Guangwei Molecules Article Cis-alkenes are ubiquitous in biological molecules, which makes it greatly significant to develop efficient methods toward construction of cis-olefins. Herein, we reported a facile semi-hydrogenation of alkynes to cis-alkenes in an efficient way with cuprous bromide/tributylphosphine as the catalyst and bis(pinacolato)diboron/methanol as the hydrogen donor. The method features convenient and facile reaction conditions, wide substrate scope, high yields, and high stereoselectivity. MDPI 2022-10-25 /pmc/articles/PMC9656742/ /pubmed/36364041 http://dx.doi.org/10.3390/molecules27217213 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zeng, Yuxi
Zhang, Honggang
Ma, Daofan
Wang, Guangwei
Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title_full Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title_fullStr Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title_full_unstemmed Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title_short Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions
title_sort copper-catalyzed diboron-mediated cis-semi-hydrogenation of alkynes under facile conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656742/
https://www.ncbi.nlm.nih.gov/pubmed/36364041
http://dx.doi.org/10.3390/molecules27217213
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AT zhanghonggang coppercatalyzeddiboronmediatedcissemihydrogenationofalkynesunderfacileconditions
AT madaofan coppercatalyzeddiboronmediatedcissemihydrogenationofalkynesunderfacileconditions
AT wangguangwei coppercatalyzeddiboronmediatedcissemihydrogenationofalkynesunderfacileconditions

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