Cargando…

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

The adenosine A(2A) and A(2B) receptors are promising therapeutic targets in the treatment of obesity and diabetes since the agonists and antagonists of these receptors have the potential to positively affect metabolic disorders. The present study investigated the link between body weight reduction,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kotańska, Magdalena, Dziubina, Anna, Szafarz, Małgorzata, Mika, Kamil, Bednarski, Marek, Nicosia, Noemi, Temirak, Ahmed, Müller, Christa E., Kieć-Kononowicz, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656786/ https://www.ncbi.nlm.nih.gov/pubmed/36362227 http://dx.doi.org/10.3390/ijms232113439

Ejemplares similares

KD-64—A new selective A(2A) adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice
por: Kotańska, Magdalena, et al.
Publicado: (2020)

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Evaluation of Some Safety Parameters of Dual Histamine H(3) and Sigma-2 Receptor Ligands with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2023)

KSK-74: Dual Histamine H(3) and Sigma-2 Receptor Ligand with Anti-Obesity Potential
por: Mika, Kamil, et al.
Publicado: (2022)

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
por: Mika, Kamil, et al.
Publicado: (2021)

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating
por: Kotańska, Magdalena, et al.
Publicado: (2021)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

Guanabenz—an old drug with a potential to decrease obesity
por: Kotańska, Magdalena, et al.
Publicado: (2022)

LC–MS–MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum—Application to Pharmacokinetic Studies
por: Szafarz, Malgorzata, et al.
Publicado: (2011)

H(3) histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice
por: Dudek, Magdalena, et al.
Publicado: (2016)

Irreversible Antagonists for the Adenosine A(2B) Receptor †
por: Temirak, Ahmed, et al.
Publicado: (2022)

Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
por: Koch, Pierre, et al.
Publicado: (2018)

Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome
por: Kubacka, Monika, et al.
Publicado: (2023)

Discovery of Potential, Dual-Active Histamine H(3) Receptor Ligands with Combined Antioxidant Properties
por: Kuder, Kamil J., et al.
Publicado: (2021)

The histamine H(3) receptor inverse agonist pitolisant reduces body weight in obese mice
por: Kotańska, Magdalena, et al.
Publicado: (2018)

A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands
por: Kuder, Kamil J., et al.
Publicado: (2020)

The Effect of Adenosine A(2A) Receptor Antagonists on Hydroxyl Radical, Dopamine, and Glutamate in the Striatum of Rats with Altered Function of VMAT2
por: Gołembiowska, Krystyna, et al.
Publicado: (2012)

Hydroalcoholic Leaf Extract of Isatis tinctoria L. via Antioxidative and Anti-Inflammatory Effects Reduces Stress-Induced Behavioral and Cellular Disorders in Mice
por: Nicosia, Noemi, et al.
Publicado: (2022)

Effect of Adenosine A(2A) Receptor Antagonists and l-DOPA on Hydroxyl Radical, Glutamate and Dopamine in the Striatum of 6-OHDA-Treated Rats
por: Gołembiowska, Krystyna, et al.
Publicado: (2011)

MH-76, a Novel Non-Quinazoline α(1)-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats
por: Kubacka, Monika, et al.
Publicado: (2021)

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice
por: Abdalla, Sabna, et al.
Publicado: (2023)

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties
por: Canale, Vittorio, et al.
Publicado: (2021)

SAT-603 Growth Hormone-Releasing Hormone (GHRH) Antagonists Stimulate Feeding in Mice
por: Leone, Sheila, et al.
Publicado: (2020)

Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders
por: Frankowska, Małgorzata, et al.
Publicado: (2023)

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
por: Bastaki, Salim M, et al.
Publicado: (2018)

R603 status and vector meson studies ($\rhô^{0} and \phi^{0}$) with the R603
por: Lockman, W, et al.
Publicado: (1974)

Pyrazolo Derivatives as Potent Adenosine Receptor Antagonists: An Overview on the Structure-Activity Relationships
por: Cheong, Siew Lee, et al.
Publicado: (2011)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
por: Sadek, Bassem, et al.
Publicado: (2016)

Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice
por: Bastaki, Salim M. A., et al.
Publicado: (2019)

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats
por: Alachkar, Alaa, et al.
Publicado: (2017)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity
por: Załuski, Michał, et al.
Publicado: (2023)

Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats
por: Alachkar, Alaa, et al.
Publicado: (2019)

Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist
por: Kotańska, Magdalena, et al.
Publicado: (2017)

Some thoughts about PSB Injection procedures
por: Bovet, C
Publicado: (1969)

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats
por: Eissa, Nermin, et al.
Publicado: (2018)

Status report of R603 and request for continuation
por: CERN. Geneva. ISR Experiments Committee
Publicado: (1974)

Observations relative to R603 Experimental Magnet
por: Lemeilleur, F
Publicado: (1974)

Characterisation of endogenous A(2A) and A(2B) receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: Evidence for an allosteric mechanism of action for the A(2B)-selective antagonist PSB 603
por: Goulding, Joelle, et al.
Publicado: (2018)

Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists
por: Prieto-Díaz, Rubén, et al.
Publicado: (2022)

The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats
por: Alachkar, Alaa, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1dvtp6pcr7307776vjg25r94vh