Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver trans...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Kang, Xu, Shanshan, Shen, Lijing, Chen, Xiaosong, Xia, Qiang, Qian, Yongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656798/
https://www.ncbi.nlm.nih.gov/pubmed/36362534
http://dx.doi.org/10.3390/jcm11216308
_version_ 1784829527887708160
author He, Kang
Xu, Shanshan
Shen, Lijing
Chen, Xiaosong
Xia, Qiang
Qian, Yongbing
author_facet He, Kang
Xu, Shanshan
Shen, Lijing
Chen, Xiaosong
Xia, Qiang
Qian, Yongbing
author_sort He, Kang
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver transplantation in adults and children. Herein, we describe a case of adult HLH triggered by cytomegalovirus (CMV) infection shortly after liver transplantation. The patient was successfully treated with ruxolitinib combined with a modified HLH-2004 treatment strategy. Our case is the first to report the successful use of ruxolitinib with a modified HLH-2004 strategy to treat HLH in a solid organ transplantation recipient.
format Online
Article
Text
id pubmed-9656798
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96567982022-11-15 Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review He, Kang Xu, Shanshan Shen, Lijing Chen, Xiaosong Xia, Qiang Qian, Yongbing J Clin Med Case Report Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver transplantation in adults and children. Herein, we describe a case of adult HLH triggered by cytomegalovirus (CMV) infection shortly after liver transplantation. The patient was successfully treated with ruxolitinib combined with a modified HLH-2004 treatment strategy. Our case is the first to report the successful use of ruxolitinib with a modified HLH-2004 strategy to treat HLH in a solid organ transplantation recipient. MDPI 2022-10-26 /pmc/articles/PMC9656798/ /pubmed/36362534 http://dx.doi.org/10.3390/jcm11216308 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
He, Kang
Xu, Shanshan
Shen, Lijing
Chen, Xiaosong
Xia, Qiang
Qian, Yongbing
Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title_full Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title_fullStr Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title_full_unstemmed Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title_short Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
title_sort ruxolitinib as adjunctive therapy for hemophagocytic lymphohistiocytosis after liver transplantation: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656798/
https://www.ncbi.nlm.nih.gov/pubmed/36362534
http://dx.doi.org/10.3390/jcm11216308
work_keys_str_mv AT hekang ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview
AT xushanshan ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview
AT shenlijing ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview
AT chenxiaosong ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview
AT xiaqiang ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview
AT qianyongbing ruxolitinibasadjunctivetherapyforhemophagocyticlymphohistiocytosisafterlivertransplantationacasereportandliteraturereview

Ejemplares similares