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Endogenous Synthesis of Tetrahydroisoquinoline Derivatives from Dietary Factors: Neurotoxicity Assessment on a 3D Neurosphere Culture

Tetrahydroisoquinoline (THIQ) alkaloids and their derivatives have a structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a well-known neurotoxin. THIQs seem to present a broad range of actions in the brain, critically dependent on their catechol moieties and metabolism. The...

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Detalles Bibliográficos
Autores principales:	Aro, Rania, Nachtergael, Amandine, Palmieri, Claudio, Ris, Laurence, Duez, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656915/ https://www.ncbi.nlm.nih.gov/pubmed/36364268 http://dx.doi.org/10.3390/molecules27217443

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