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Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications

Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small...

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Autores principales: Esmaeilpour, Donya, Broscheit, Jens Albert, Shityakov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656986/
https://www.ncbi.nlm.nih.gov/pubmed/36362293
http://dx.doi.org/10.3390/ijms232113505
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author Esmaeilpour, Donya
Broscheit, Jens Albert
Shityakov, Sergey
author_facet Esmaeilpour, Donya
Broscheit, Jens Albert
Shityakov, Sergey
author_sort Esmaeilpour, Donya
collection PubMed
description Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.
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spelling pubmed-96569862022-11-15 Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications Esmaeilpour, Donya Broscheit, Jens Albert Shityakov, Sergey Int J Mol Sci Review Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies. MDPI 2022-11-04 /pmc/articles/PMC9656986/ /pubmed/36362293 http://dx.doi.org/10.3390/ijms232113505 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Esmaeilpour, Donya
Broscheit, Jens Albert
Shityakov, Sergey
Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title_full Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title_fullStr Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title_full_unstemmed Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title_short Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
title_sort cyclodextrin-based polymeric materials bound to corona protein for theranostic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656986/
https://www.ncbi.nlm.nih.gov/pubmed/36362293
http://dx.doi.org/10.3390/ijms232113505
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