Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule

Different serum thyroxine levels may influence the morphology of the inner ear during development. A well-developed organ of Corti (OC) is considered to be critical to the function of hearing. In our study, we treated mice with triiodothyronine (T3) and found that the opening of the OC occurred soon...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Huimin, Xie, Le, Chen, Sen, Qiu, Yue, Sun, Yu, Kong, Weijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656988/
https://www.ncbi.nlm.nih.gov/pubmed/36362134
http://dx.doi.org/10.3390/ijms232113339
_version_ 1784829577534636032
author Zhang, Huimin
Xie, Le
Chen, Sen
Qiu, Yue
Sun, Yu
Kong, Weijia
author_facet Zhang, Huimin
Xie, Le
Chen, Sen
Qiu, Yue
Sun, Yu
Kong, Weijia
author_sort Zhang, Huimin
collection PubMed
description Different serum thyroxine levels may influence the morphology of the inner ear during development. A well-developed organ of Corti (OC) is considered to be critical to the function of hearing. In our study, we treated mice with triiodothyronine (T3) and found that the opening of the OC occurred sooner than in control mice. We also observed an increased formation of acetylated microtubules and a decrease in the adhesion junction molecule P-cadherin the during opening of the OC. Our investigation indicates that thyroxin affects P-cadherin expression and microtubule acetylation to influence the opening of the OC.
format Online
Article
Text
id pubmed-9656988
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96569882022-11-15 Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule Zhang, Huimin Xie, Le Chen, Sen Qiu, Yue Sun, Yu Kong, Weijia Int J Mol Sci Article Different serum thyroxine levels may influence the morphology of the inner ear during development. A well-developed organ of Corti (OC) is considered to be critical to the function of hearing. In our study, we treated mice with triiodothyronine (T3) and found that the opening of the OC occurred sooner than in control mice. We also observed an increased formation of acetylated microtubules and a decrease in the adhesion junction molecule P-cadherin the during opening of the OC. Our investigation indicates that thyroxin affects P-cadherin expression and microtubule acetylation to influence the opening of the OC. MDPI 2022-11-01 /pmc/articles/PMC9656988/ /pubmed/36362134 http://dx.doi.org/10.3390/ijms232113339 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Huimin
Xie, Le
Chen, Sen
Qiu, Yue
Sun, Yu
Kong, Weijia
Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title_full Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title_fullStr Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title_full_unstemmed Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title_short Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
title_sort thyroxine regulates the opening of the organ of corti through affecting p-cadherin and acetylated microtubule
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656988/
https://www.ncbi.nlm.nih.gov/pubmed/36362134
http://dx.doi.org/10.3390/ijms232113339
work_keys_str_mv AT zhanghuimin thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule
AT xiele thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule
AT chensen thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule
AT qiuyue thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule
AT sunyu thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule
AT kongweijia thyroxineregulatestheopeningoftheorganofcortithroughaffectingpcadherinandacetylatedmicrotubule

Ejemplares similares