Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology

Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural products or their derivatives. Thus, natural products play significant roles in clinical cancer therapy. With the...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, He, Yu, Jian, Meiling, Fu, Xingang, Cheng, Yuheng, He, Yujia, Fang, Jun, Li, Lin, Zhang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656990/
https://www.ncbi.nlm.nih.gov/pubmed/36364307
http://dx.doi.org/10.3390/molecules27217480
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author Wang, Haibo
He, Yu
Jian, Meiling
Fu, Xingang
Cheng, Yuheng
He, Yujia
Fang, Jun
Li, Lin
Zhang, Dan
author_facet Wang, Haibo
He, Yu
Jian, Meiling
Fu, Xingang
Cheng, Yuheng
He, Yujia
Fang, Jun
Li, Lin
Zhang, Dan
author_sort Wang, Haibo
collection PubMed
description Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural products or their derivatives. Thus, natural products play significant roles in clinical cancer therapy. With the development of biosynthetic technologies, an increasing number of natural products have been discovered and developed as candidates for clinical cancer therapy. Here, we aim to summarize the anticancer natural products approved from 1950 to 2021 and discuss their molecular mechanisms. We also describe the available synthetic biology tools and highlight their applications in the development of natural products.
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spelling pubmed-96569902022-11-15 Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology Wang, Haibo He, Yu Jian, Meiling Fu, Xingang Cheng, Yuheng He, Yujia Fang, Jun Li, Lin Zhang, Dan Molecules Review Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural products or their derivatives. Thus, natural products play significant roles in clinical cancer therapy. With the development of biosynthetic technologies, an increasing number of natural products have been discovered and developed as candidates for clinical cancer therapy. Here, we aim to summarize the anticancer natural products approved from 1950 to 2021 and discuss their molecular mechanisms. We also describe the available synthetic biology tools and highlight their applications in the development of natural products. MDPI 2022-11-02 /pmc/articles/PMC9656990/ /pubmed/36364307 http://dx.doi.org/10.3390/molecules27217480 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Haibo
He, Yu
Jian, Meiling
Fu, Xingang
Cheng, Yuheng
He, Yujia
Fang, Jun
Li, Lin
Zhang, Dan
Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title_full Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title_fullStr Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title_full_unstemmed Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title_short Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology
title_sort breaking the bottleneck in anticancer drug development: efficient utilization of synthetic biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656990/
https://www.ncbi.nlm.nih.gov/pubmed/36364307
http://dx.doi.org/10.3390/molecules27217480
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