Cargando…

Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues

SIMPLE SUMMARY: Accumulating evidence indicates the existence of cancer stem cells (CSCs) sub-populations which fuel cancer growth and maintain stemness in different cancers. In addition to the genetic and phenotypic variabilities that differentiate CSCs from non-CSCs counterparts, CSCs adopt a flex...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Yunong, Ma, Stephanie, Tong, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657081/
https://www.ncbi.nlm.nih.gov/pubmed/36358763
http://dx.doi.org/10.3390/cancers14215345
_version_ 1784829601917173760
author Xie, Yunong
Ma, Stephanie
Tong, Man
author_facet Xie, Yunong
Ma, Stephanie
Tong, Man
author_sort Xie, Yunong
collection PubMed
description SIMPLE SUMMARY: Accumulating evidence indicates the existence of cancer stem cells (CSCs) sub-populations which fuel cancer growth and maintain stemness in different cancers. In addition to the genetic and phenotypic variabilities that differentiate CSCs from non-CSCs counterparts, CSCs adopt a flexible metabolic strategy to sustain their oncogenic and stemness properties, in order to survive and propagate in a hostile tumor microenvironment (TME). TME factors and metabolites exert context-dependent influence on cancer stemness. In addition, the metabolic landscape in TME is complicated by the crosstalk between CSCs and tumor-infiltrating cells. In this review, we will summarize the metabolic interaction between CSCs and various microenvironmental factors and review how this interplay regulates cancer stemness and tumorigenesis. ABSTRACT: An increasing body of evidence suggests that cancer stem cells (CSCs) utilize reprogrammed metabolic strategies to adapt to a hostile tumor microenvironment (TME) for survival and stemness maintenance. Such a metabolic alteration in CSCs is facilitated by microenvironmental cues including metabolites such as glucose, amino acids and lipids, and environmental properties such as hypoxic and acidic TME. Similarly, metabolites uptake from the diet exerts critical imprints to the metabolism profile of CSCs and directly influence the maintenance of the CSC population. Moreover, CSCs interact with tumor-infiltrating cells inside the CSC niche to promote cancer stemness, ultimately contributing to tumor development and progression. Understanding the underlying mechanisms of how CSCs employ metabolic plasticity in response to different microenvironmental cues represents a therapeutic opportunity for better cancer treatment.
format Online
Article
Text
id pubmed-9657081
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96570812022-11-15 Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues Xie, Yunong Ma, Stephanie Tong, Man Cancers (Basel) Review SIMPLE SUMMARY: Accumulating evidence indicates the existence of cancer stem cells (CSCs) sub-populations which fuel cancer growth and maintain stemness in different cancers. In addition to the genetic and phenotypic variabilities that differentiate CSCs from non-CSCs counterparts, CSCs adopt a flexible metabolic strategy to sustain their oncogenic and stemness properties, in order to survive and propagate in a hostile tumor microenvironment (TME). TME factors and metabolites exert context-dependent influence on cancer stemness. In addition, the metabolic landscape in TME is complicated by the crosstalk between CSCs and tumor-infiltrating cells. In this review, we will summarize the metabolic interaction between CSCs and various microenvironmental factors and review how this interplay regulates cancer stemness and tumorigenesis. ABSTRACT: An increasing body of evidence suggests that cancer stem cells (CSCs) utilize reprogrammed metabolic strategies to adapt to a hostile tumor microenvironment (TME) for survival and stemness maintenance. Such a metabolic alteration in CSCs is facilitated by microenvironmental cues including metabolites such as glucose, amino acids and lipids, and environmental properties such as hypoxic and acidic TME. Similarly, metabolites uptake from the diet exerts critical imprints to the metabolism profile of CSCs and directly influence the maintenance of the CSC population. Moreover, CSCs interact with tumor-infiltrating cells inside the CSC niche to promote cancer stemness, ultimately contributing to tumor development and progression. Understanding the underlying mechanisms of how CSCs employ metabolic plasticity in response to different microenvironmental cues represents a therapeutic opportunity for better cancer treatment. MDPI 2022-10-29 /pmc/articles/PMC9657081/ /pubmed/36358763 http://dx.doi.org/10.3390/cancers14215345 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xie, Yunong
Ma, Stephanie
Tong, Man
Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title_full Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title_fullStr Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title_full_unstemmed Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title_short Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues
title_sort metabolic plasticity of cancer stem cells in response to microenvironmental cues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657081/
https://www.ncbi.nlm.nih.gov/pubmed/36358763
http://dx.doi.org/10.3390/cancers14215345
work_keys_str_mv AT xieyunong metabolicplasticityofcancerstemcellsinresponsetomicroenvironmentalcues
AT mastephanie metabolicplasticityofcancerstemcellsinresponsetomicroenvironmentalcues
AT tongman metabolicplasticityofcancerstemcellsinresponsetomicroenvironmentalcues