The biological function of m6A methyltransferase KIAA1429 and its role in human disease

KIAA1429 is a major m6A methyltransferase, which plays important biological and pharmacological roles in both human cancer or non-cancer diseases. KIAA1429 produce a tumorigenic role in various cancers through regulating DAPK3, ID2, GATA3, SMC1A, CDK1, SIRT1 and other targets, promoting cell prolife...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoyu, Li, Meng jiao, Xia, Lei, Zhang, Hairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657180/
https://www.ncbi.nlm.nih.gov/pubmed/36389416
http://dx.doi.org/10.7717/peerj.14334
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author Zhang, Xiaoyu
Li, Meng jiao
Xia, Lei
Zhang, Hairong
author_facet Zhang, Xiaoyu
Li, Meng jiao
Xia, Lei
Zhang, Hairong
author_sort Zhang, Xiaoyu
collection PubMed
description KIAA1429 is a major m6A methyltransferase, which plays important biological and pharmacological roles in both human cancer or non-cancer diseases. KIAA1429 produce a tumorigenic role in various cancers through regulating DAPK3, ID2, GATA3, SMC1A, CDK1, SIRT1 and other targets, promoting cell proliferation, migration, invasion, metastasis and tumor growth . At the same time, KIAA1429 is also effective in non-tumor diseases, such as reproductive system and cardiovascular system diseases. The potential regulatory mechanism of KIAA1429 dependent on m6A modification is related to mRNA, lncRNA, circRNA and miRNAs. In this review, we summarized the current evidence on KIAA1429 in various human cancers or non-cancer diseases and its potential as a prognostic target.
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spelling pubmed-96571802022-11-15 The biological function of m6A methyltransferase KIAA1429 and its role in human disease Zhang, Xiaoyu Li, Meng jiao Xia, Lei Zhang, Hairong PeerJ Molecular Biology KIAA1429 is a major m6A methyltransferase, which plays important biological and pharmacological roles in both human cancer or non-cancer diseases. KIAA1429 produce a tumorigenic role in various cancers through regulating DAPK3, ID2, GATA3, SMC1A, CDK1, SIRT1 and other targets, promoting cell proliferation, migration, invasion, metastasis and tumor growth . At the same time, KIAA1429 is also effective in non-tumor diseases, such as reproductive system and cardiovascular system diseases. The potential regulatory mechanism of KIAA1429 dependent on m6A modification is related to mRNA, lncRNA, circRNA and miRNAs. In this review, we summarized the current evidence on KIAA1429 in various human cancers or non-cancer diseases and its potential as a prognostic target. PeerJ Inc. 2022-11-10 /pmc/articles/PMC9657180/ /pubmed/36389416 http://dx.doi.org/10.7717/peerj.14334 Text en ©2022 Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Molecular Biology
Zhang, Xiaoyu
Li, Meng jiao
Xia, Lei
Zhang, Hairong
The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title_full The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title_fullStr The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title_full_unstemmed The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title_short The biological function of m6A methyltransferase KIAA1429 and its role in human disease
title_sort biological function of m6a methyltransferase kiaa1429 and its role in human disease
topic Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657180/
https://www.ncbi.nlm.nih.gov/pubmed/36389416
http://dx.doi.org/10.7717/peerj.14334
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