Cargando…

Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease

Elevated levels of matrix metalloprotease 9 (MMP-9) and neutrophil elastase (NE) are associated with bronchiectasis and lung function decline in patients with cystic fibrosis (CF). MMP-9 is a potent extracellular matrix-degrading enzyme which is activated by NE and has been implicated in structural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagner, Claudius, Balázs, Anita, Schatterny, Jolanthe, Zhou-Suckow, Zhe, Duerr, Julia, Schultz, Carsten, Mall, Marcus A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657231/ https://www.ncbi.nlm.nih.gov/pubmed/36362203 http://dx.doi.org/10.3390/ijms232113405

Ejemplares similares

Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease
por: Wagner, Claudius J., et al.
Publicado: (2016)

CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in βENaC-Overexpressing Mice
por: Johannesson, Bjarki, et al.
Publicado: (2012)

Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease
por: Galluzzo, Maria, et al.
Publicado: (2015)

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis
por: Balázs, Anita, et al.
Publicado: (2018)

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
por: Hey, Joschka, et al.
Publicado: (2021)

Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction
por: Marcos, Veronica, et al.
Publicado: (2015)

DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine
por: Kiefer, Alexander, et al.
Publicado: (2022)

New Developments in Cystic Fibrosis Airway Inflammation
por: Palaniyar, Nades, et al.
Publicado: (2015)

Quantification of Phenotypic Variability of Lung Disease in Children with Cystic Fibrosis
por: Stahl, Mirjam, et al.
Publicado: (2021)

Role of the SLC26A9 Chloride Channel as Disease Modifier and Potential Therapeutic Target in Cystic Fibrosis
por: Balázs, Anita, et al.
Publicado: (2018)

MDCT-based longitudinal automated airway and air trapping analysis in school-age children with mild cystic fibrosis lung disease
por: Weinheimer, Oliver, et al.
Publicado: (2023)

Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis
por: Frey, Dario L., et al.
Publicado: (2022)

BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease
por: Bingle, Lynne, et al.
Publicado: (2012)

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice
por: Leitz, Dominik H. W., et al.
Publicado: (2021)

Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease
por: Tucker, Samantha L., et al.
Publicado: (2021)

Personalized CFTR Modulator Therapy for G85E and N1303K Homozygous Patients with Cystic Fibrosis
por: Graeber, Simon Y., et al.
Publicado: (2023)

The Chitinase-Like Protein YKL-40 Modulates Cystic Fibrosis Lung Disease
por: Hector, Andreas, et al.
Publicado: (2011)

Characterizing Lung Disease in Cystic Fibrosis with Magnetic Resonance Imaging and Airway Physiology
por: Theilmann, Rebecca J., et al.
Publicado: (2016)

Upper Airway Findings and Markers of Lung Disease Progression in Patients with Cystic Fibrosis
por: Steffen, Luciane Mazzini, et al.
Publicado: (2020)

Airway epithelial stem cell chimerism in cystic fibrosis lung transplant recipients
por: Hayes, Don, et al.
Publicado: (2021)

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6
por: Oglesby, Irene K, et al.
Publicado: (2015)

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
por: Yadav, Ruchi, et al.
Publicado: (2023)

Lung Microbiome in Cystic Fibrosis
por: Scialo, Filippo, et al.
Publicado: (2021)

A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis
por: Metzger, Marisa I., et al.
Publicado: (2021)

Achromobacter xylosoxidans airway infection is associated with lung disease severity in children with cystic fibrosis
por: Marsac, Charlotte, et al.
Publicado: (2021)

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease
por: Steinke, Eva, et al.
Publicado: (2023)

Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis
por: Montgomery, Samuel T., et al.
Publicado: (2020)

The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis
por: Cuthbertson, Leah, et al.
Publicado: (2021)

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
por: Duerr, Julia, et al.
Publicado: (2020)

Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
por: Pezzulo, Alejandro A., et al.
Publicado: (2012)

Changes in Cystic Fibrosis Airway Microbial Community Associated with a Severe Decline in Lung Function
por: Paganin, Patrizia, et al.
Publicado: (2015)

A Different Microbiome Gene Repertoire in the Airways of Cystic Fibrosis Patients with Severe Lung Disease
por: Bacci, Giovanni, et al.
Publicado: (2017)

Untargeted Metagenomic Investigation of the Airway Microbiome of Cystic Fibrosis Patients with Moderate-Severe Lung Disease
por: Bacci, Giovanni, et al.
Publicado: (2020)

Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
por: Kirst, Mariana E., et al.
Publicado: (2019)

70329 Automated Lungs Segmentation and Airways Skeletonization from CT Scans in Patients with Cystic Fibrosis
por: Chong Chie, Juan A., et al.
Publicado: (2021)

CFTR Modulator Therapy and Its Impact on Lung Transplantation in Cystic Fibrosis
por: Benden, Christian, et al.
Publicado: (2021)

The Gut-Lung Axis in Cystic Fibrosis
por: Price, Courtney E., et al.
Publicado: (2021)

Comparison of Microbiomes from Different Niches of Upper and Lower Airways in Children and Adolescents with Cystic Fibrosis
por: Boutin, Sébastien, et al.
Publicado: (2015)

Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
por: Hirche, T. O., et al.
Publicado: (2014)

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis
por: Bergin, David A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4rupol2mrksol0dqcqjkj00n76