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STING Targeting in Lung Diseases

The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the contex...

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Autores principales: de Moura Rodrigues, Dorian, Lacerda-Queiroz, Norinne, Couillin, Isabelle, Riteau, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657237/
https://www.ncbi.nlm.nih.gov/pubmed/36359882
http://dx.doi.org/10.3390/cells11213483
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author de Moura Rodrigues, Dorian
Lacerda-Queiroz, Norinne
Couillin, Isabelle
Riteau, Nicolas
author_facet de Moura Rodrigues, Dorian
Lacerda-Queiroz, Norinne
Couillin, Isabelle
Riteau, Nicolas
author_sort de Moura Rodrigues, Dorian
collection PubMed
description The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy.
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spelling pubmed-96572372022-11-15 STING Targeting in Lung Diseases de Moura Rodrigues, Dorian Lacerda-Queiroz, Norinne Couillin, Isabelle Riteau, Nicolas Cells Review The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy. MDPI 2022-11-03 /pmc/articles/PMC9657237/ /pubmed/36359882 http://dx.doi.org/10.3390/cells11213483 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Moura Rodrigues, Dorian
Lacerda-Queiroz, Norinne
Couillin, Isabelle
Riteau, Nicolas
STING Targeting in Lung Diseases
title STING Targeting in Lung Diseases
title_full STING Targeting in Lung Diseases
title_fullStr STING Targeting in Lung Diseases
title_full_unstemmed STING Targeting in Lung Diseases
title_short STING Targeting in Lung Diseases
title_sort sting targeting in lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657237/
https://www.ncbi.nlm.nih.gov/pubmed/36359882
http://dx.doi.org/10.3390/cells11213483
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