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STING Targeting in Lung Diseases
The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the contex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657237/ https://www.ncbi.nlm.nih.gov/pubmed/36359882 http://dx.doi.org/10.3390/cells11213483 |
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author | de Moura Rodrigues, Dorian Lacerda-Queiroz, Norinne Couillin, Isabelle Riteau, Nicolas |
author_facet | de Moura Rodrigues, Dorian Lacerda-Queiroz, Norinne Couillin, Isabelle Riteau, Nicolas |
author_sort | de Moura Rodrigues, Dorian |
collection | PubMed |
description | The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy. |
format | Online Article Text |
id | pubmed-9657237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96572372022-11-15 STING Targeting in Lung Diseases de Moura Rodrigues, Dorian Lacerda-Queiroz, Norinne Couillin, Isabelle Riteau, Nicolas Cells Review The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy. MDPI 2022-11-03 /pmc/articles/PMC9657237/ /pubmed/36359882 http://dx.doi.org/10.3390/cells11213483 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Moura Rodrigues, Dorian Lacerda-Queiroz, Norinne Couillin, Isabelle Riteau, Nicolas STING Targeting in Lung Diseases |
title | STING Targeting in Lung Diseases |
title_full | STING Targeting in Lung Diseases |
title_fullStr | STING Targeting in Lung Diseases |
title_full_unstemmed | STING Targeting in Lung Diseases |
title_short | STING Targeting in Lung Diseases |
title_sort | sting targeting in lung diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657237/ https://www.ncbi.nlm.nih.gov/pubmed/36359882 http://dx.doi.org/10.3390/cells11213483 |
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